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Overview

Uniprot ID	A0A5G2QKZ6
Protein Name	Laminin subunit beta-1
Gene Name	LAMB1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1198	LEKAKALKISGVIGP
246	NLRIKFVKLHTLGDN
626	ITVQRPGKIPTSSRC

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway

Protein Sequence

10 MAGTPALCLC 20 PMLLSAPSTA 30 LCGAQVSAQE 40 PEFSYGCAEG 50 SCYPATGDLL 60 IGRAQKLSVT 70 STCGLHKPEP 80 YCIVSHLQED 90 KKCFICNSQD 100 PYHETLNPDS 110 HLIENVVTTF 120 APNRLKIWWQ 130 SENGVENVTI 140 QLDLEAEFHF 150 THLIMTFKTF 160 RPAAMLIERS 170 SDFGRTWGVY 180 RYFAYDCESS 190 FPGIPTGPMK 200 KVDDIICDSR 210 YSDIEPSTEG 220 EVIFRALDPA 230 FRIEDPYSPR 240 IQNLLKITNL 250 RIKFVKLHTL 260 GDNLLDSRME 270 IREKYYYAVY 280 DMVVRGNCFC 290 YGHASECAPV 300 DGFNEEVEGM 310 VHGHCMCRHN 320 TKGLNCELCM 330 DFYHDLPWRP 340 AEGRNSNACK 350 KCNCNEHSSS 360 CHFDMAVYLA 370 TGNVSGGVCD 380 DCQHNTMGRN 390 CERCKPFYYQ 400 HPERDVRDPN 410 LCEPCTCDPA 420 GSQNGCRCKL 430 HVEGEHCDIC 440 KEGFYGLTAE 450 DPFGCKSCAC 460 NPLGTIPGGN 470 PCDSETGYCY 480 CKRLVTGQHC 490 DQCLPEHWGL 500 SNDLDGCRPC 510 DCDLGGALNN 520 SCSAESGQCL 530 CRPHMIGRQC 540 NEVESGFYFT 550 TLDHYIYEAE 560 EANFGPGVSI 570 VERQYVQDRI 580 PSWTGAGFVR 590 VPEGAYLEFF 600 IDNIPYSMEY 610 DILIRYEPQL 620 PDHWEKAVIT 630 VQRPGKIPTS 640 SRCGNTVPDD 650 DNQVVSLSPG 660 SRYVVLPRPV 670 CFEKGVNYTV 680 RLELPQYTSS 690 DSSVDSPYTL 700 IDSLVLMPFC 710 KSLDIFTVGS 720 SGDGVVTNSA 730 WEMFQRYRCL 740 ENSRSVVKTP 750 MTDVCRNIIF 760 SISALLHQTG 770 LACECDPQGS 780 LSSVCDPNGG 790 QCQCRPNVVG 800 RKCDRCAPGT 810 FGFGPNGCKP 820 CECHLQGSVN 830 AFCDPVTGQC 840 HCFQGVYARQ 850 CDRCLPGYWG 860 FPSCQPCQCN 870 GHAEDCDSVT 880 GECSSCQDYT 890 TGHNCERCLA 900 GYYGDAIIGS 910 GDHCRPCPCP 920 DGPESGRQFA 930 SSCYQDPVTL 940 QLACVCNPGY 950 IGSRCEDCAA 960 GFFGNPSEVG 970 GTCQPCQCHH 980 NIDTTDPEAC 990 DKETGRCLKC 1000 LYHTEGVHCQ 1010 LCRLGYYGDA 1020 LQQDCRKCVC 1030 NYLGTVQEHC 1040 NGSDCQCDKT 1050 TGQCLCLPNV 1060 IGQNCDRCAP 1070 NTWQLASGTG 1080 CEPCNCDAAH 1090 SFGPSCNEFT 1100 GQCQCMPGFG 1110 GRTCSECQEL 1120 FWGDPSVECR 1130 ACDCDPRGIE 1140 TPQCDQSTGQ 1150 CVCVEGVEGP 1160 RCDKCTRGYS 1170 GVFPDCTPCH 1180 QCFALWDVII 1190 AELTNRTQKF 1200 LEKAKALKIS 1210 GVIGPYRETV 1220 DSVEKKVNEI 1230 RDILAQSPAA 1240 EPLKNIGNLF 1250 EEAEKLTKDV 1260 TEKMAQVEGK 1270 LSDAALQSNS 1280 TARELDSLQA 1290 EAESLENTVK 1300 ELAEQLEFIK 1310 NSDIRGALDS 1320 ITKYFQMSLE 1330 AEERVNASTT 1340 DSNSTVEQSA 1350 LIRDRVEDLM 1360 LEQESQFRDK 1370 QEEQARLLDE 1380 LAGKLQSLDL 1390 STAAELTCGT 1400 PPGASCSETE 1410 CGGPNCRTDE 1420 GQKKCGGPGC 1430 GGLVTVAHSA 1440 WQKAMDFDQD 1450 VLSALAEVEQ 1460 LSKMVSEAKL 1470 RADEAKQNAQ 1480 DVLLKANATK 1490 EKVDKSNEDL 1500 RNLIKQIRDF 1510 LTQDSADLDS 1520 IEAVANEVLK 1530 MEMPSTPQQL 1540 QNLTEDIRER 1550 VESLSQVEVI 1560 LQQSAADIAR 1570 AELLLEEAQR 1580 ASKSATDVKV 1590 TADMVKEALE 1600 EAEKAQIAAE 1610 KAIKQADEDI 1620 QGTQNLLTSI 1630 ESETAASEET 1640 LFNASQRISE 1650 LERNVEELKR 1660 KAAQNSGEAE 1670 YIEKVVYAVK 1680 QSADDVKKTL 1690 DGELEEKYKK 1700 VENLIAQKTE 1710 ESADARRKAE 1720 MLQNEAKTLL 1730 AQANSKLQLL 1740 KDLERKYEDN 1750 QKYLEDKAQE 1760 LVRLEGEVRS 1770 LLKDISQKVA VYSTCL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005606	laminin-111 trimer
Cellular Component	GO:0043259	laminin-511 trimer
Biological Process	GO:0007155	cell adhesion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.