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Overview

Uniprot ID	A0A5G2QKZ8
Protein Name	Elongation factor G, mitochondrial
Gene Name	GFM1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
327	RNYQGELKKGDTIYN
468	GCPCITGKPKVAFRE

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRLLGAAAAA 20 AAVGRGPLPR 30 IPAALGWPGK 40 QANWKICRWC 50 SSGVIPNEKI 60 RNIGISAHID 70 SGKTTLTERV 80 LYYTGRIAKM 90 HEVKGKDGVG 100 AVMDSMELER 110 QRGITIQSAA 120 TYTLWKDVNI 130 NIIDTPGHVD 140 FTIEVERALR 150 VLDGAILVLC 160 AVGGVQCQTM 170 TVNRQMQRYS 180 VPFLTFINKL 190 DRMGSNPTRA 200 LQQMRSKLNH 210 NAALVQIPIG 220 LEGDFKGIID 230 LIEERAIYFD 240 GDFGATINRS 250 FTPVFLGSAL 260 KNKGVQPLLD 270 AVVEYLPNPS 280 EVQNYAILNQ 290 DDSQEKTKIL 300 MNSKRDDSHP 310 FVGLAFKLEA 320 GRFGQLTYVR 330 NYQGELKKGD 340 TIYNTRTRKK 350 VRVQRLVRMH 360 ADMMEDVEEV 370 FAGDICALFG 380 IDCASGDTFT 390 NKENSGLSME 400 SIHVPDPVIS 410 IAMKPSNKND 420 LEKFSKGIGR 430 FTREDPTFKV 440 HFDTESKETI 450 VSGMGELHLE 460 IYAQRMEREY 470 GCPCITGKPK 480 VAFRETITAP 490 VPFEFTHKKQ 500 SGGAGQFGKV 510 IGVLEPLDPE 520 NYTKLEFSDE 530 TFGANVPKQF 540 VPAVEKGFLD 550 ACEKGPLSGH 560 KLSGLRFVLQ 570 DGAHHMVDSN 580 EISFIRAGEG 590 ALKQALANAT 600 VCILEPIMSV 610 EVIAPNEFQG 620 PVIAGINRRH 630 GVITGQDGVE 640 DYFTVYAEVP 650 LNDMFGYSTE 660 LRSCTEGKGE 670 YTMEYCRYQP 680 CSPATQEDLV 690 NKYLEATGQL PVKKGKAKN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0070125	mitochondrial translational elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.