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Overview

Uniprot IDA0A5G2QL80
Protein NameRibonucleoside-diphosphate reductase
Gene NameRRM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
153 LERSYLLKISGKVAE
409 YKDSCNRKSNQQNLG
466 TKLAEVTKVIVRNLN

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Protein Sequence

10 DGRQERVMFD 20 KITSRIQKLC 30 YGLNMDFVDP 40 AQITMKVIQG 50 LYSGVTTVEL 60 DTLAAETAAT 70 LTTKHPDYAI 80 LAARIAVSNL 90 HKETKKVFSD 100 VMEDLFNYIN 110 PHNGKHSPMV 120 ASQRWIFATQ 130 QDLLRLNSAI 140 IYDRDFSYNY 150 FGFKTLERSY 160 LLKISGKVAE 170 RPQHMLMRVS 180 VGIHKEDIDA 190 AIETYNLLSE 200 KWFTHASPTL 210 FNAGTNRPQL 220 SSCFLLSMKD 230 DSIEGIYDTL 240 KQCALISKSA 250 GGIGVAVSCI 260 RATGSYIAGT 270 NGNSNGLVPM 280 LRVYNNTARY 290 VDQGGNKRPG 300 AFAIYLEPWH 310 LDIFEFLDLK 320 KNTGKEEQRA 330 RDLFFALWIP 340 DLFMKRVETN 350 QDWSLMCPNE 360 CPGLDEVWGE 370 EFEKLYESYE 380 RQGHVRKVVK 390 AQQLWYAIIE 400 SQTETGTPYM 410 LYKDSCNRKS 420 NQQNLGTIKC 430 SNLCTEIVEY 440 TSKDEVAVCN 450 LASLALNMYV 460 TSEHTYDFTK 470 LAEVTKVIVR 480 NLNKIIDINY 490 YPIPEASLSN 500 KRHRPIGIGV 510 QGLADAFILM 520 RYPFESPEAQ 530 LLNKQIFETI 540 YYGALEASCD 550 LAKEYGPYET 560 YEGSPVSKGI 570 LQYDMWNVTP 580 TDLWDWKLLK 590 EKIAKYGIRN 600 SLLIAPMPTA 610 STAQILGNNE 620 SIEPYTSNIY 630 TRRVLSGEFQ 640 IVNPHLLKDL 650 TERGLWNEEM 660 KNQIIACNGS 670 IQSIPEIPDD 680 LKQLYKTVWE 690 ISQKTVLKMA 700 AERGAFIDQS 710 QSLNIHIAEP 720 NYGKLTSMHF 730 YGWKQGLKTG 740 MYYLRTRPAA 750 NPIQFTLNKE 760 KLKDKEKVSK 770 EEEKERNTAA 780 MVCSLENRDE CLMCGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005971 ribonucleoside-diphosphate reductase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Process GO:0009265 2'-deoxyribonucleotide biosynthetic process
Biological Process GO:0006264 mitochondrial DNA replication
Biological Process GO:0070318 positive regulation of G0 to G1 transition
Biological Process GO:0009185 ribonucleoside diphosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.