Overview
| Uniprot ID | A0A5G2QL81 |
|---|
| Protein Name | Proteasome subunit alpha type |
|---|
| Gene Name | PSMA4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 225 |
NKTMDVSKLSAEKVE |
| 230 |
VSKLSAEKVEIATLT |
| 251 |
VIRVLKQKEVEQLIK |
| 258 |
KEVEQLIKKHEEEEA |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MICGLCFLLL
20
GRNHLFIFPL
30
QSRRYDSRTT
40
IFSPEGRLYQ
50
VEYAMEAIGH
60
AGTCLGILAN
70
DGVLLAAERR
80
NIHKLLDEVF
90
FSEKIYKLNE
100
DMACSVAGIT
110
SDANVLTNEL
120
RLIAQRYLLQ
130
YQEPIPCEQL
140
VTALCDIKQA
150
YTQFGGKRPF
160
GVSLLYIGWD
170
KHYGFQLYQS
180
DPSGNYGGWK
190
ATCIGNNSAA
200
AVSMLKQDYK
210
EGEMTLKSAL
220
ALAIKVLNKT
230
MDVSKLSAEK
240
VEIATLTREN
250
GKTVIRVLKQ
260
KEVEQLIKKH
270
EEEEAKAERE
280
KKEKEQKEKD
K
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0006979 |
response to oxidative stress |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000932 |
P-body |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.