Search Results
Overview
| Uniprot ID | A0A5G2QL83 |
|---|---|
| Protein Name | SUMO-activating enzyme subunit 1 |
| Gene Name | SAE1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | CSRDVIVKVDQICHK |
| 183 | EEKTKVAKVSQGVED |
| 195 | VEDGPDTKRAKLDSS |
| 198 | GPDTKRAKLDSSETT |
| 210 | ETTMVKKKVVFCSVK |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2
Protein Sequence
10
MVEKEEAGGG
20
ISEEEAAQYD
30
RQIRLWGLEA
40
QKRLRASRVL
50
LVGMKGLGAE
60
IAKNLILAGV
70
KGLTMLDHEQ
80
VSPEDPGAQF
90
LIRTGSVGRN
100
RAEASLERAQ
110
NLNPMVDVKV
120
DTENIENKPE
130
SFFTQFDAVC
140
LTCCSRDVIV
150
KVDQICHKNS
160
IKFFTGDVFG
170
YHGYTFANLG
180
EHEFVEEKTK
190
VAKVSQGVED
200
GPDTKRAKLD
210
SSETTMVKKK
220
VVFCSVKEAL
230
EVDWSSDKAK
240
AALKRTTSDY
250
FLLQVLLKFR
260
TDKGRDPSSD
270
TFGEDSELLL
280
QIRNDVLDSL
290
GVNPDLLPED
300
FVRYCFSEMA
310
PVCAVVGGIL
320
AQEIVKVKVT
330
VESKTIDPLH
340
HPLVDVPAER
350
TQDCLSKLPG
360
LSAVTHPFFL
370
PSPSSSFLFP
380
PHPILSSPSS
WAFSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0031510 | SUMO activating enzyme complex |
| Molecular Function | GO:0043008 | ATP-dependent protein binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0044388 | small protein activating enzyme binding |
| Molecular Function | GO:0019948 | SUMO activating enzyme activity |
| Biological Process | GO:0033235 | positive regulation of protein sumoylation |
| Biological Process | GO:0016925 | protein sumoylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.