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Overview

Uniprot IDA0A5G2QLB4
Protein NameRibonucleoside-diphosphate reductase
Gene NameRRM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
154 LERSYLLKISGKVAE
410 YKDSCNRKSNQQNLG
467 TKLAEVTKVIVRNLN

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Protein Sequence

10 MHRVMFDKIT 20 SRIQKLCYGL 30 NMDFVDPAQI 40 TMKVIQGLYS 50 GVTTVELDTL 60 AAETAATLTT 70 KHPDYAILAA 80 RIAVSNLHKE 90 TKKVFSDVME 100 DLFNYINPHN 110 DVCIIENESN 120 YLKLSFVFFF 130 FSLHQRLNSA 140 IIYDRDFSYN 150 YFGFKTLERS 160 YLLKISGKVA 170 ERPQHMLMRV 180 SVGIHKEDID 190 AAIETYNLLS 200 EKWFTHASPT 210 LFNAGTNRPQ 220 LSSCFLLSMK 230 DDSIEGIYDT 240 LKQCALISKS 250 AGGIGVAVSC 260 IRATGSYIAG 270 TNGNSNGLVP 280 MLRVYNNTAR 290 YVDQGGNKRP 300 GAFAIYLEPW 310 HLDIFEFLDL 320 KKNTGKEEQR 330 ARDLFFALWI 340 PDLFMKRVET 350 NQDWSLMCPN 360 ECPGLDEVWG 370 EEFEKLYESY 380 ERQGHVRKVV 390 KAQQLWYAII 400 ESQTETGTPY 410 MLYKDSCNRK 420 SNQQNLGTIK 430 CSNLCTEIVE 440 YTSKDEVAVC 450 NLASLALNMY 460 VTSEHTYDFT 470 KLAEVTKVIV 480 RNLNKIIDIN 490 YYPIPEASLS 500 NKRHRPIGIG 510 VQGLADAFIL 520 MRYPFESPEA 530 QLLNKQIFET 540 IYYGALEASC 550 DLAKEYGPYE 560 TYEGSPVSKG 570 ILQYDMWNVT 580 PTDLWDWKLL 590 KEKIAKYGIR 600 NSLLIAPMPT 610 ASTAQILGNN 620 ESIEPYTSNI 630 YTRRVLSGEF 640 QIVNPHLLKD 650 LTERGLWNEE 660 MKNQIIACNG 670 SIQSIPEIPD 680 DLKQLYKTVW 690 EISQKTVLKM 700 AAERGAFIDQ 710 SQSLNIHIAE 720 PNYGKLTSMH 730 FYGWKQGLKT 740 GMYYLRTRPA 750 ANPIQFTLNK 760 EKLKDKEKVS 770 KEEEKERNTA 780 AMVCSLENRD ECLMCGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005971 ribonucleoside-diphosphate reductase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Process GO:0009265 2'-deoxyribonucleotide biosynthetic process
Biological Process GO:0006264 mitochondrial DNA replication
Biological Process GO:0070318 positive regulation of G0 to G1 transition
Biological Process GO:0009185 ribonucleoside diphosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.