Search Results

Overview

Uniprot ID	A0A5G2QLC9
Protein Name	Nuclear receptor corepressor 1
Gene Name	NCOR1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
107	DHDSLESKRPRLEQV
1082	TRGTPSGKLPVESVP
1174	TAHEISLKRSYESVE
1264	AFEGAISKGKPYDGI
1334	SAIKHNVKSLITGPS
1342	SLITGPSKLPRGLPP
1398	STLHEAPKAQLSPGI
1448	KSTNHERKSTLTPTQ
1818	SSALPSGKPQPHPAV
201	KVEQQILKLKKKQQQ
2250	CKPKLISKSSSRKSK
283	ARKQREQKICQRYDQ
321	KTREYYEKQFPEIRK
648	KNFYFNYKRRHNLDN
661	DNLLQQHKQKTSRKP

Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver

Protein Sequence

10 MSSSGYPPNQ 20 GAFSTEQSRY 30 PSHSVQYTFP 40 SARHQQEFAV 50 PDYRSSHLEV 60 SQASQLLQQQ 70 QQQQLRRRPS 80 LLSEFHPGSD 90 RPQERRSGYE 100 QFHPGPSPVD 110 HDSLESKRPR 120 LEQVSDSHFQ 130 RISAAVLPLV 140 HTLPEGLRSS 150 ADAKKDPAFG 160 VKHEAPSSPL 170 SGQPCGDDQN 180 ASPSKLSKEE 190 LIQSMDRVDR 200 EIAKVEQQIL 210 KLKKKQQQLE 220 EEAAKPPEPE 230 KPVSPPPVEQ 240 KHRSIVQIIY 250 DENRPLYNQP 260 SDTKLKTIYS 270 VMRKKLILFF 280 KRRNHARKQR 290 EQKICQRYDQ 300 LMEAWEKKVD 310 RIENNPRRKA 320 KESKTREYYE 330 KQFPEIRKQR 340 EQQERFQRVG 350 QRGAGLSATI 360 ARSEHEISEI 370 IDGLSEQENN 380 EKQMRQLSVI 390 PPMMFDAEQR 400 RVKFINMNGL 410 MEDPMKVYKD 420 RQFMNVWTDH 430 EKEIFKDKFI 440 QHPKNFGLIA 450 SYLERKSVPD 460 CVLYYYLTKK 470 NENYKALVRR 480 NYGKRRGRNQ 490 QQIARPSQEE 500 KVEEKEDDKA 510 EKTEKKEEEK 520 KDEEEKDEKE 530 DSKETTKEKD 540 KTEGTAEEAE 550 EREQATPRGR 560 KTANSQGRRK 570 GRVTRSMTNE 580 AAAASAAAAA 590 ATEEPPPPLP 600 PPPEPISTEP 610 VETSRWTEEE 620 MEVAKKGLVE 630 HGRNWAAIAK 640 MVGTKSEAQC 650 KNFYFNYKRR 660 HNLDNLLQQH 670 KQKTSRKPRE 680 ERDVSQCESV 690 ASTVSAQEDE 700 DIEASNEEEN 710 PEDSEGAENS 720 SDTESAPSPS 730 PVEAVKPGED 740 RTEPAAQPEA 750 PAPGASPPRP 760 PPARPRTEPM 770 DAGPEERGAD 780 AAPAPGPPAA 790 EPADPEPRAP 800 GSPGRVDGDT 810 VQPEPREDGA 820 PRPEPASDHD 830 SSATCSADED 840 VDAEPDRQRM 850 FPLDSKPSLL 860 NPTGSMLVSS 870 PIKANPLDLP 880 QLQHRAAVIP 890 PMVSCTPCNI 900 PVGTPVSGYA 910 LYQRHIKAMH 920 ESALLEEQRQ 930 RQEQIDLECR 940 GSTSPCGASK 950 SPGREWEVLQ 960 PAPHQVIANL 970 PEGVRLPTTR 980 PTRPPPPLIP 990 SSKTAVASEK 1000 PSFILGGSIS 1010 QASYAPEAAK 1020 PPAGSISLGL 1030 PRPQEAAKPA 1040 AVPYIKQEEF 1050 SPRSQNSQPE 1060 GLLVRAQHEG 1070 VVRGSTGAIA 1080 EGSITRGTPS 1090 GKLPVESVPS 1100 LRGSITQGTP 1110 ALSQAGIPAE 1120 ALVKGSISRL 1130 SVEESSPEKG 1140 REEAASKGHV 1150 IYEGKSGHIL 1160 SYDNIKNARE 1170 GTRSPRTAHE 1180 ISLKRSYESV 1190 EGALKQGLPV 1200 RESPGSTPLE 1210 GLICRALPRG 1220 SPHPDLKERT 1230 VPSGSIMQGT 1240 PRATADSFED 1250 GLKYPKQIKR 1260 ESPPIRAFEG 1270 AISKGKPYDG 1280 ITTIKEMGRS 1290 VHEIPRQDAL 1300 TQESRKTPEV 1310 VPGARPLVEG 1320 SISQGTPIKF 1330 DSSSGQSAIK 1340 HNVKSLITGP 1350 SKLPRGLPPL 1360 EVVPEGAKAV 1370 ERGKYEDVKA 1380 GEPVRSRHTS 1390 VVSSGPSVLR 1400 STLHEAPKAQ 1410 LSPGIYDEAS 1420 ARRTPGSYAS 1430 PASRGSPMLG 1440 RAPDVTIASG 1450 KSTNHERKST 1460 LTPTQRESIV 1470 AKSPVPGVDP 1480 AVSHSPFEPH 1490 HRAGAPGEAY 1500 RGHLPTHLDP 1510 AMPFHRALDP 1520 AAAAYLFQRQ 1530 LSPTPGYPSQ 1540 YQLYAMENTR 1550 QTILNDYITS 1560 QQMQVSLRPD 1570 VARGLSPREQ 1580 QLGLPYPATR 1590 GIIDLTNMPP 1600 AILVPHPGGT 1610 STPPMDRITY 1620 IPGTQISFPP 1630 RPYNSASMSP 1640 GHSTHLAVAA 1650 SAEREREKER 1660 ERLAAAAAAS 1670 SDLYLRPGSE 1680 QPSRPSSHGY 1690 VRSPSPSVRA 1700 QETVLQQRPS 1710 VFQGTNGTSV 1720 ITPLDPSAQL 1730 RIMPLPAGGP 1740 SISQGLPASR 1750 YNTAADALAA 1760 LVDAAASAPQ 1770 MDVSKTKESK 1780 HEAARLEENL 1790 RSRSAAVSEQ 1800 QQLEQKSLEA 1810 EKRPGQGLYT 1820 SSALPSGKPQ 1830 PHPAVVYSEA 1840 GREKGPPPKS 1850 RYEEELRTRG 1860 KTTITAANFI 1870 DVIITRQIAS 1880 DKDGRERGSQ 1890 SSDSSGSLSS 1900 HRYEAPSDAI 1910 EVISPASSPA 1920 PPPERLQAYQ 1930 PEVVKASPAE 1940 NEATRQYEGP 1950 LHHYRPQQES 1960 PPPAAPQAEG 1970 AGQVPRTHRL 1980 ITLADHICQI 1990 ITQDFARNQV 2000 SAQPPQQPPT 2010 STFQNSPSAL 2020 VSTPVRPKTS 2030 NRYSPESQPP 2040 SVHHQRPGSR 2050 VSPENLVDKP 2060 RGRPGKSPER 2070 SHISSEPYEP 2080 VSPPQVPAAH 2090 EKQDGVLLLA 2100 PRGPEPPEQR 2110 SDSRSPGSIS 2120 YLPSFFTKLE 2130 NTSPMVKSKK 2140 QEIFRKLNSS 2150 GGGDSDMAAA 2160 QPGTEIFNLP 2170 AVTTSGAVSS 2180 RGHTFADPAS 2190 NLGLEDIIRK 2200 ALMGSFDDKV 2210 EEHGGVLPQP 2220 GAVVPGGAGT 2230 SVVSSGEARR 2240 EEGDPPPHAG 2250 AVCKPKLISK 2260 SSSRKSKSPI 2270 PGQGYLGTER 2280 PSSVSSVHSE 2290 GDYHRQTPGW 2300 AWEDRPSSTG 2310 STQFPYNPLT 2320 LRMLSSTPPT 2330 PVACAPAATA 2340 AAPAAPHQQS 2350 RIWEREPAPL 2360 LSAQYETLSD SDD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0017053	transcription repressor complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0016922	nuclear receptor binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:1902532	negative regulation of intracellular signal transduction
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0048511	rhythmic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.