Overview
| Uniprot ID | A0A5G2QLQ1 |
|---|
| Protein Name | Acetyltransferase component of pyruvate dehydrogenase complex |
|---|
| Gene Name | DLAT |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 352 |
PATPAGPKGRLFVSP |
| 362 |
LFVSPLAKKLASEKG |
| 376 |
GIDLTQIKGTGPDGR |
| 387 |
PDGRIIKKDIDSFVP |
| 473 |
KMLEGRSKISVNDFI |
Function
The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation
Protein Sequence
10
MWRVCARRAQ
20
NAAPRAGFGA
30
RWTALREEPG
40
APCAAPRAGS
50
VPARCSSTTR
60
GYGRSRALCG
70
WSASSWATPQ
80
NRILLQLWGS
90
PNRRWYSLPP
100
HQKVPLPSLS
110
PTMQAGTIAR
120
WEKKEGDKIN
130
EGELIAEVET
140
DKATVGFESL
150
EECYMAKILV
160
AEGTRDVPVG
170
AIICITVEKP
180
EDIEAFKNYT
190
LDSSAAPAPQ
200
AAPAPTPAAA
210
APAPTPSAQA
220
PGSSYPTHMQ
230
VVLPALSPTM
240
TMGTVQRWEK
250
KVGEKLSEGD
260
LLAEIETDKA
270
TIGFEVQEEG
280
YLAKILIPEG
290
TRDVPLGTPL
300
CIIVEKEADI
310
PAFADYRPTE
320
VTDLKPPAPP
330
PTPSPVTPVP
340
PAPQPVAPTP
350
AATRPATPAG
360
PKGRLFVSPL
370
AKKLASEKGI
380
DLTQIKGTGP
390
DGRIIKKDID
400
SFVPTKAAPP
410
PAAAVPPPSP
420
GVAPVPTGVF
430
TDIPISNIRR
440
VIAQRLMQSK
450
QTIPHYYLSV
460
DVNMGEVLLV
470
RKELNKMLEG
480
RSKISVNDFI
490
IKASALACLK
500
VPEANSSWLD
510
TVIRQNHVVD
520
ISVAVSTPAG
530
LITPIVFNAH
540
IKGLETIAND
550
VVSLATKARE
560
GKLQPHEFQG
570
GTFTISNLGM
580
FGIKNFSAII
590
NPPQACILAV
600
GASEDRLFPA
610
DNEKGFDVAS
620
MMSVTLSCDH
630
RVVDGAVGAQ
640
WLAEFRKYLE
KPITMLL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045254 |
pyruvate dehydrogenase complex |
| Molecular Function |
GO:0004742 |
dihydrolipoyllysine-residue acetyltransferase activity |
| Biological Process |
GO:0006006 |
glucose metabolic process |
| Biological Process |
GO:0006086 |
pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.