Search Results
Overview
| Uniprot ID | A0A5G2QM19 |
|---|---|
| Protein Name | Xaa-Pro dipeptidase |
| Gene Name | PEPD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | RLCERLRKNPAVQAG |
| 529 | ACMAGRDKAFVPFSG |
Function
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen
Protein Sequence
10
RAATPGPSFW
20
LGNETLKVPL
30
ALFVLNRRRL
40
CERLRKNPAV
50
QAGSVVVLQG
60
GEETQRYCTD
70
TGVLFRQESF
80
FHWAFGVTEP
90
GCYGVIDIDS
100
GTSTLFVPRL
110
PPSHATWMGK
120
IHSKEHFKEK
130
YAVDDVHYAD
140
EIASVLTSRS
150
PSVLLTLRGV
160
NTDSGSVCRE
170
ASFEGISKFN
180
VNNTILHPEI
190
VECRVFKTDM
200
ELEVLRYTNK
210
ISSEAHREVM
220
KAVKVGMKEY
230
EMERPCLCSL
240
PGAYPTLFCL
250
PAGLPLKSIF
260
QARTQRLLLS
270
PPCIHPSLSL
280
FEHYCYSRGG
290
MRHSSYTCIC
300
GSGENSAVLH
310
YGHAGAPNDR
320
TIQDGDMCLF
330
DMGGEYYCFA
340
SDITCSFPAN
350
GKFTEDQKAI
360
YEAVLRSCRA
370
VMNSMKPGVW
380
WPDMHRLADR
390
VHLEELTRIG
400
ILTGSVDAMV
410
QVHLGAVFMP
420
HGLGHFLGID
430
VHDVGGYPEG
440
VERIDEPGLR
450
SLRTARHLQA
460
GMVLTVEPGI
470
YFIDHLLDEA
480
LADPARACFF
490
NCEVLQRFRG
500
FGGVRIEEDV
510
VVTNSGMELL
520
TCVPRTVEEI
530
EACMAGRDKA
FVPFSGPK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Molecular Function | GO:0102009 | proline dipeptidase activity |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0043069 | negative regulation of programmed cell death |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.