Search Results
Overview
| Uniprot ID | A0A5G2QMB0 |
|---|---|
| Protein Name | Glutathione S-transferase P |
| Gene Name | LOC100739163 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | YTNYEAGKEKYVKEL |
| 80 | RSFGLYGKDQKEAAL |
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration
Protein Sequence
10
VPPYTITYFP
20
VRGRCEAMRM
30
LLADQDQSWK
40
EEVVTMETWP
50
PLKPSCLFRQ
60
LPKFQDGDLT
70
LYQSNAILRH
80
LGRSFGLYGK
90
DQKEAALVDM
100
VNDGVEDLRC
110
KYATLIYTNY
120
EAGKEKYVKE
130
LPEHLKPFET
140
LLSQNQGGQA
150
FVVGSQISFA
160
DYNLLDLLRI
170
HQVLNPSCLD
180
AFPLLSAYVA
190
RLSARPKIKA
200
FLASPEHVNR
210
PINGNGKQAE
220
AFRWTGLVRA
230
QPIECKRIKD
240
TKADHEIPEP
250
PESKDLPERE
260
KPTPQTRDKA
270
FQSYQIPCDN
280
GTGLPPSSIS
VPSSGS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.