Search Results
Overview
| Uniprot ID | A0A5G2QMC4 |
|---|---|
| Protein Name | Cysteine and histidine-rich domain-containing protein 1 |
| Gene Name | CHORDC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | LKISASLKQALDKLK |
| 198 | YWSCCRRKTSDFNTF |
| 215 | QEGCTTGKHAWTKKD |
| 44 | LKGWSCCKRRTTDFS |
Function
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling. Involved in stress response. Prevents tumorigenesis
Protein Sequence
10
MALLCYNRGC
20
GQRFDPETNS
30
DDACTYHPGV
40
PVFHDALKGW
50
SCCKRRTTDF
60
SDFLSIAGCT
70
KGRHNSEKPP
80
EPVKPEVKTT
90
EKKELSELKP
100
RFQEHIIQAP
110
KPVEAIKRPS
120
PDEPMTNLEL
130
KISASLKQAL
140
DKLKLSSGNE
150
ENKKEEDSDE
160
IKVGTSCKNG
170
GCSKTYQGPQ
180
SLEEVCVYHS
190
GVPIFHEGMK
200
YWSCCRRKTS
210
DFNTFLAQEG
220
CTTGKHAWTK
230
KDAGKKVVPC
240
RHDWHQTGGE
250
VTISVYAKNS
260
LPELSQVVAN
270
STLLNVHIVF
280
EGEKEFHQNV
290
KLWGVIDVKR
300
SYVTMTATKI
310
EITMRKAEPM
320
QWASLELPAA
330
KNQEKQKEDT
AE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:1900034 | regulation of cellular response to heat |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.