Search Results
Overview
| Uniprot ID | A0A5G2QMV2 |
|---|---|
| Protein Name | Xaa-Pro dipeptidase |
| Gene Name | PEPD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | RLCERLRKNPAVQAG |
| 443 | ACMAGRDKAFVPFSG |
Function
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen
Protein Sequence
10
MAAATGPSFW
20
LGNETLKVPL
30
ALFVLNRRRL
40
CERLRKNPAV
50
QAGSVVVLQG
60
GEETQRYCTD
70
TGVLFRQESF
80
FHWAFGVTEP
90
GCYGVIDIDS
100
GTSTLFVPRL
110
PPSHATWMGK
120
IHSKEHFKEK
130
YAVDDVHYAD
140
EIASVLTSRS
150
PSVLLTLRGV
160
NTDSGSVCRE
170
ASFEGISKFN
180
VNNTILHPEI
190
VECLFEHYCY
200
SRGGMRHSSY
210
TCICGSGENS
220
AVLHYGHAGA
230
PNDRTIQDGD
240
MCLFDMGGEY
250
YCFASDITCS
260
FPANGKFTED
270
QKAIYEAVLR
280
SCRAVMNSMK
290
PGVWWPDMHR
300
LADRVHLEEL
310
TRIGILTGSV
320
DAMVQVHLGA
330
VFMPHGLGHF
340
LGIDVHDVGG
350
YPEGVERIDE
360
PGLRSLRTAR
370
HLQAGMVLTV
380
EPGIYFIDHL
390
LDEALADPAR
400
ACFFNCEVLQ
410
RFRGFGGVRI
420
EEDVVVTNSG
430
MELLTCVPRT
440
VEEIEACMAG
450
RDKAFVPFSG
PK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0102009 | proline dipeptidase activity |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.