Search Results
Overview
| Uniprot ID | A0A5G2QMY1 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | DCTN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 231 | DKFSQAAKVAELEKR |
| 237 | AKVAELEKRLTELEA |
| 305 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MADPKYADLP
20
GIARNEPDVY
30
ETSDLPEDDQ
40
AEFDAVRPCE
50
ELTSTSVEHI
60
IVNPNAAYDK
70
FKDKRVGTKG
80
LDLTDSYRIG
90
KTKRTGYESG
100
EYEMLGEGLG
110
VKETPQQKYQ
120
RLLHEVQELT
130
TEVEKIKMTV
140
KESATEEKLT
150
PVVLAKQLAA
160
LKQQLVASHL
170
EKLLGPDAAI
180
NLTDPDGALA
190
KRLLLQLEAT
200
KNTKGAGSGG
210
KTTSGSPPDS
220
SLVTYELHSR
230
PEQDKFSQAA
240
KVAELEKRLT
250
ELEATVRCDQ
260
DAQNPLSAGL
270
QGACLMETVE
280
LLQAKVSALD
290
LAVLDQVEAR
300
LQSVLGKVNE
310
IAKHKASVED
320
ADTQSKVHQL
330
YETIQRWSPI
340
ASTLPELVQR
350
LVTIKQLHEQ
360
AMQFGQLLTH
370
LDTTQQMIAC
380
SLKDNATLLT
390
QVQTTMRENL
400
STVEGNFANI
DERMKKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030507 | spectrin binding |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0007052 | mitotic spindle organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.