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Overview

Uniprot IDA0A5G2QNM8
Protein NameCoatomer subunit gamma
Gene NameCOPG1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
177 QAIERYMKQAIVDKV
207 KCSFDVVKRWVNEAQ
245 NDRLAVSKMISKFTR
330 AAVRTLNKVAMKHPS
406 AISALCQKYPRKHAV
482 LLGQEGPKTNNPSKY
488 PKTNNPSKYIRFIYN
828 HPCERSDKVPDNKNT
833 SDKVPDNKNTHTLLL

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins

Protein Sequence

10 MKIWHYERHR 20 RTVQGCWVKW 30 FAVAGTPLQE 40 SGRIYWQVVI 50 AILRSWYFIG 60 WTVRHLSLDC 70 DWENFEIQSG 80 GSNPFQHLEK 90 SAVLQEARVF 100 NETPVNPRKC 110 AHILTKILYL 120 INQPTLRRMC 130 YLTIKEMSCI 140 AEDVIIVTSS 150 LTKDMTGKED 160 NYRGPAVRAL 170 CQITDSTMLQ 180 AIERYMKQAI 190 VDKVPSVSSS 200 ALVSSLHLLK 210 CSFDVVKRWV 220 NEAQEAASSD 230 NIMVQYHALG 240 LLYHVRKNDR 250 LAVSKMISKF 260 TRHGLKSPFA 270 YCMMIRVASR 280 QLEEEDGSPL 290 FDFIESSASA 300 IVNLPGCSAK 310 ELAPAVSVLQ 320 LFCSSPKAAL 330 RYAAVRTLNK 340 VAMKHPSAVT 350 ACNLDLENLV 360 TDSNRSIATL 370 AITTLLKTGS 380 EGSIDRLMKQ 390 ISSFMSEISD 400 EFKVVVVQAI 410 SALCQKYPRK 420 HAVLMNFLFS 430 MLREEGGFEY 440 KRAIVDCIIS 450 IIEENAESKE 460 TGLSHLCEFI 470 EDCEFTVLAT 480 RILHLLGQEG 490 PKTNNPSKYI 500 RFIYNRVVLE 510 HEEVRAGAVS 520 ALAKFGAQNE 530 EMLPSILVLL 540 KRCVMDDDNE 550 VRDRATFYLN 560 VLEQKQKALN 570 AGYILNGLTV 580 SIPGLERALQ 590 QYTLEPSEKP 600 FDLKSVPLAT 610 TPMAEQRTAK 620 QPEKVAATRQ 630 EIFQEQLAAV 640 PEFQGLGPLF 650 KSSPEPVALT 660 ESETEYVIRC 670 TKHTFTNHMV 680 FQFDCTNTLN 690 DQTLENVTVQ 700 MEPTEAYEVL 710 CYVPARSLPY 720 NQPGTCYTLV 730 ALPKEDPTAV 740 ACTFSCMMKF 750 TVKDCDPTTG 760 ETDDEGYEDE 770 YVLEDLEVTI 780 ADHIQKVMKL 790 NFEAAWDEVG 800 DEFEKEETFT 810 LSTIKTLEEA 820 VGNIVKFLGM 830 HPCERSDKVP 840 DNKNTHTLLL 850 AGVFRGGHDI 860 LVRSRLLLLD 870 TVTMQVTARS 880 SEELPVDIVL ASVG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0072384 organelle transport along microtubule
Biological Process GO:0009306 protein secretion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.