Search Results
Overview
| Uniprot ID | A0A5G2QNU8 |
|---|---|
| Protein Name | Protein enabled homolog |
| Gene Name | ENAH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | VYDDANKKWVPAGGS |
| 441 | RRRRIAEKGSTIETE |
| 52 | TFRVVGRKIQDHQVV |
| 554 | RKELTKLKEELIDAI |
| 66 | VINCAIPKGLKYNQA |
| 69 | CAIPKGLKYNQATQT |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation
Protein Sequence
10
MSEQSICQAR
20
AAVMVYDDAN
30
KKWVPAGGST
40
GFSRVHIYHH
50
TGNNTFRVVG
60
RKIQDHQVVI
70
NCAIPKGLKY
80
NQATQTFHQW
90
RDARQVYGLN
100
FGSKEDANVF
110
ASAMMHALEV
120
LNSQEAGPTL
130
PRQNSQLPAQ
140
VQNGPSQEEL
150
EIQRRQLQEQ
160
QRQKELERER
170
LERERMERER
180
LERERLERER
190
LERERLEQEQ
200
LERERQERER
210
QERQERLERE
220
RQERERLERL
230
ERLDRERQER
240
ERQEQLEREQ
250
LEWERERRVS
260
SAAAPASVET
270
PLNSVLGDSS
280
ASEPGLQAAS
290
QPAETPAQQG
300
IVLGPPAPPP
310
PPPLPPGPAQ
320
ASAILPPPPG
330
PPPPPPLPSS
340
GPPPPPPPPP
350
LPNQAPPPPP
360
PPPAPPLPAS
370
GFFSGSMSED
380
NRPLTGLAAA
390
IAGAKLRKVS
400
RMEDGSFPSG
410
VNAASSKTDT
420
GRGNGPLPLG
430
GSGLMEEMSA
440
LLARRRRIAE
450
KGSTIETEQK
460
EDKNEDSEPQ
470
TSKASSTSTP
480
EPTRKPWERT
490
NTMNGSKSPV
500
ISRRDSSRKN
510
QIVFDNRSYD
520
SLHRPKSAPS
530
SQPSANGVQT
540
EGLDYDRLKQ
550
DILDEMRKEL
560
TKLKEELIDA
570
IRQELSKSNT
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.