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Overview

Uniprot IDA0A5G2QP65
Protein NameInner nuclear membrane protein Man1
Gene NameLEMD3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
819 DGKLVTVKYLRLDRY

Function

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest

Protein Sequence

10 MAAAAASAPQ 20 QLSDEELFSQ 30 LRRYGLSPGP 40 VTESTRPVYL 50 KKLKKLREEE 60 QQQHRSGGRG 70 TKTRNSNNNN 80 TAAATVAAAG 90 STVAAAGMGV 100 RPVSGDLSYL 110 RTPGGLGRIS 120 TSGPESPLGG 130 TGGASAAPTA 140 GSKVVLGFSS 150 DESDVEASPR 160 DQAGGGGGRK 170 DRAPLQYRGL 180 KPPSAPLTAS 190 EVTNNNSAER 200 RKPHSWWGAR 210 RSAAPELQSP 220 SGRDGAAEDE 230 EQEGEDGEDR 240 DPEAEEPLWS 250 GRTVNGSRLL 260 PYSCRENYSD 270 SEEEDDDDVA 280 SSRQVLKDDS 290 LSRHRLRRGH 300 SKPLSPLPAK 310 SAGGRLETSV 320 QGRGGIAMND 330 RAAAAGSLDR 340 SRNLEEPAAA 350 EQGGGCDPLD 360 SSPIPRYRVN 370 AKKLAPLLPP 380 PLADMDSTLD 390 SSTGSLLKTN 400 NHIGGGAFNV 410 DSPRIFSNSL 420 PPGAAVAASG 430 SLRINHSNHT 440 GSNHTYLKNT 450 YNKPKLSEPE 460 EELLQQFKRE 470 EVSPTGGFSA 480 HYLSMFLLTA 490 ACLFFLILGL 500 TYLGMRGTGV 510 TEDGELTIKN 520 PFDETFGKIQ 530 DLGPEYEDIF 540 NISLQWIFEN 550 GKDVGIRCVG 560 YDPEEELTDM 570 VDVQFLQSTR 580 PQMSFWCRFR 590 RAFITVTHRL 600 LLLCLGVVMV 610 CVVLRYMKYR 620 WTKEEEETRQ 630 MYDMVVKIID 640 VLRSHNEACQ 650 ENKDLQPYMP 660 IPHVRDSLIQ 670 PHDRKKMKKV 680 WDRAVDFLAA 690 NESRVRTETR 700 RIGGTDFLVW 710 RWIQPSASCD 720 KILVIPSKVW 730 QGQAFHLDRR 740 NSPPNSLTPC 750 LKIRNMFDPV 760 MEIGDQWHLA 770 IQEAILEKCS 780 DNDGIVHIAV 790 DKNSREGCVY 800 VKCLSPEYAG 810 KAFKALHGSW 820 FDGKLVTVKY 830 LRLDRYHHRF 840 PQALTCNTPL 850 KPSNKHMNSM 860 SHLRLRTGLA NSQGGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005637 nuclear inner membrane
Molecular Function GO:0003677 DNA binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.