Search Results

Overview

Uniprot ID	A0A5G2QP74
Protein Name	Rho-associated protein kinase
Gene Name	ROCK2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1182	KKFGWVKKYVIVSSK
1189	KYVIVSSKKILFYDS
1249	ANEGESKKEQEFPVE
614	NNRDLQDKNCLLETA
768	NLLLEAEKRCSILDC
811	KIEQETQKRCLTQND
893	KTQVRELKEECEEKT
904	EEKTKLCKELQQKKQ
910	CKELQQKKQELQDER

Function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity

Protein Sequence

10 MGFPCSAAET 20 NPTSICEGAS 30 LILSLAQWVG 40 GSGVAESPGN 50 FHLTSFFFLF 60 LCFVKQDGLN 70 SLVLDLDFPA 80 LRKNKNIDNF 90 LNRYEKIVKK 100 IRGLQMKAED 110 YDVVKVIGRG 120 AFGEVQLVRH 130 KASQKVYAMK 140 LLSKFEMIKR 150 SDSAFFWEER 160 DIMAFANSPW 170 VVQLFCAFQD 180 DKYLYMVMEY 190 MPGGDLVNLM 200 SNYDVPEKWA 210 KFYTAEVVLA 220 LDAIHSMGLI 230 HRDVKPDNML 240 LDKHGHLKLA 250 DFGTCMKMDE 260 TGMVHCDTAV 270 GTPDYISPEV 280 LKSQGGDGYY 290 GRECDWWSVG 300 VFLFEMLVGD 310 TPFYADSLVG 320 TYSKIMDHKN 330 SLCFPEDAEI 340 SKHAKNLICA 350 FLTDREVRLG 360 RNGVEEIKQH 370 PFFKNDQWNW 380 DNIRETAAPV 390 VPELSSDIDS 400 SNFDDIEDDK 410 GDVETFPIPK 420 AFVGNQLPFI 430 GFTYYRENLL 440 LSDSPSCKEN 450 DSIQIRKNEE 460 SQEIQKKLYT 470 LEEHLSTEIQ 480 AKEELEQKCK 490 SVNTRLEKVA 500 KELEEEIALR 510 KNVESALRQL 520 EREKALLQHK 530 NAEYQRKADH 540 EADKKRNLEN 550 DVNSLKDQLE 560 DLKKRNQNSQ 570 ISTEKVNQLQ 580 RQLDETNALL 590 RTESDTAARL 600 RKTQAESSKQ 610 IQQLESNNRD 620 LQDKNCLLET 630 AKLKLEKDFI 640 NLQSVLESER 650 RDRTHGSEII 660 NDLQGRISGL 670 EEDLKNGKIL 680 LTKVEMEKRQ 690 LQERFTDLEK 700 EKNNMEIDMT 710 YQLKVIQQSL 720 EQEEAEHKAT 730 KARLADKNKI 740 YESIEEAKSE 750 AMKEMEKKLL 760 EERTLKQKVE 770 NLLLEAEKRC 780 SILDCDLKQS 790 QQKINELLKQ 800 KDVLNEDVRN 810 LTLKIEQETQ 820 KRCLTQNDLK 830 MQTQQVNTLK 840 MSEKQLKQEN 850 NHLMEMKMSL 860 EKQNAELRKE 870 RQDADGQMKE 880 LQDQLEAEQY 890 FSTLYKTQVR 900 ELKEECEEKT 910 KLCKELQQKK 920 QELQDERDSL 930 AAQLEITLTK 940 ADSEQLARSI 950 AEEQYSDLEK 960 EKIMKELEIK 970 EMMARHKQEL 980 TEKDTTIASL 990 EETNRTLTSD 1000 VANLANEKEE 1010 LNNKLKDAQE 1020 QLSRLKDEEI 1030 SAAAIKAQFE 1040 KQLLTERTLK 1050 TQAVNKLAEI 1060 MNRKEPVKRG 1070 NDTDMRRKEK 1080 ENRKLHMELK 1090 SEREKLTQQM 1100 IKYQKELNEM 1110 QAQIAEESQI 1120 RIELQMTLDS 1130 KDSDIEQLRS 1140 QLQALHIGLD 1150 SSSIGSGPGD 1160 AEADDGFPES 1170 RLEGWLSLPV 1180 RNNTKKFGWV 1190 KKYVIVSSKK 1200 ILFYDSEQDK 1210 EQSNPYMVLD 1220 IDKLFHVRPV 1230 TQTDVYRADA 1240 KEIPRIFQIL 1250 YANEGESKKE 1260 QEFPVEPVGE 1270 KSNCICHKGH 1280 EFIPTLYHFP 1290 TNCEACMKPL 1300 WHMFKPPPAL 1310 ECRRCHIKCH 1320 KDHMDKKEEI 1330 IAPCKVYYDI 1340 SSAKNLLLLA 1350 NSTEEQQKWV 1360 SRLVKKIPKK 1370 PPAPDPFARS 1380 SPRTSMKIQQ 1390 NQSIRRPSRQ LAANKPS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0061133	endopeptidase activator activity
Molecular Function	GO:0002020	protease binding
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity
Molecular Function	GO:0031267	small GTPase binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0051298	centrosome duplication
Biological Process	GO:0044788	host-mediated perturbation of viral process
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process
Biological Process	GO:0150033	negative regulation of protein localization to lysosome
Biological Process	GO:1902004	positive regulation of amyloid-beta formation
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0010825	positive regulation of centrosome duplication
Biological Process	GO:1902966	positive regulation of protein localization to early endosome
Biological Process	GO:0051496	positive regulation of stress fiber assembly
Biological Process	GO:0072659	protein localization to plasma membrane
Biological Process	GO:1903140	regulation of establishment of endothelial barrier
Biological Process	GO:0045616	regulation of keratinocyte differentiation
Biological Process	GO:0007266	Rho protein signal transduction
Biological Process	GO:0048511	rhythmic process
Biological Process	GO:0006939	smooth muscle contraction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.