Search Results
Overview
| Uniprot ID | A0A5G2QPA8 |
|---|---|
| Protein Name | NAD(P)H-hydrate epimerase |
| Gene Name | NAXE |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 248 | YYPKRPNKPLFTALV |
| 346 | ISLTAPKKSAAQFTG |
Function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis
Protein Sequence
10
MKNYYQRAVG
20
SKALPVISEA
30
IRKCSRGGLG
40
SRLEEKAHGH
50
RQTPAGRVRK
60
ATSRGGASAA
70
DPRTAFGRSA
80
CGPGLSGAGQ
90
SAAQAPGRPG
100
RAGGARPASW
110
MSGLRALLGL
120
GLLVAGSRLP
130
RVRVQAGACR
140
ARPTWWGPQR
150
LISGGRGDVE
160
GMASSAVKYL
170
SQEEAQAVDQ
180
ELFNEYQFSV
190
DQLMELAGLS
200
CATAIAKAYP
210
PTSLSRSPPT
220
VLVICGPGNN
230
GGDGLVCARH
240
LKLFGYQPTI
250
YYPKRPNKPL
260
FTALVTQCQK
270
MDIPFLDEMP
280
SEPTLIDELY
290
ELVVDAIFGF
300
SFKGEVREPF
310
RSILSVLNGL
320
TVPIASIDIP
330
SGWDVERGNS
340
GGIQPDLLIS
350
LTAPKKSAAQ
360
FTGRYHYLGG
370
RFVPPALEKK
380
YQLNLPPYPD
TECVYRLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0052856 | NAD(P)HX epimerase activity |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006869 | lipid transport |
| Biological Process | GO:0031580 | membrane raft distribution |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
| Biological Process | GO:0010874 | regulation of cholesterol efflux |
| Biological Process | GO:0002040 | sprouting angiogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.