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Overview

Uniprot IDA0A5G2QPB2
Protein NameSorting nexin
Gene NameSNX6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
195 RGKNKKEKLEDFFKN
288 KVSELFDKTRKIEAR
319 LRESQAAKDLLYRRS
371 EKISESAKQELIDFK

Function

Involved in several stages of intracellular trafficking

Protein Sequence

10 VRACAGCRFG 20 AAMMEGLDDG 30 PDFLSDEDRG 40 LKAINVDLQS 50 DAALQVDISD 60 ALSERDKVKF 70 TVHTKSSLPN 80 FKQNEFSVVR 90 QHEEFIWLHD 100 SFVENEDYAG 110 YIIPPAPPRP 120 DFDASREKLQ 130 KLGEGEGSMT 140 KEEFTKMKQE 150 LEAEYLAIFK 160 KTVAMHEVFL 170 CRVAAHPILR 180 KDLNFHVFLE 190 YNQDLSVRGK 200 NKKEKLEDFF 210 KNMVKSADGV 220 IVSGVKDVDD 230 FFEHERTFLL 240 EYHNRVKDAS 250 AKSDRMTRSH 260 KSAADDYNRI 270 GSSLYALGTQ 280 DSTDICKFFL 290 KVSELFDKTR 300 KIEARVSADE 310 DLKLSDLLKY 320 YLRESQAAKD 330 LLYRRSRSLV 340 DYENANKALD 350 KARAKNKDVL 360 QAETSQQLCC 370 QKFEKISESA 380 KQELIDFKTR 390 RVAAFRKNLV 400 ELAELELKHA 410 KGNLQLLQNC LAVLNGDT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005764 lysosome
Cellular Component GO:0098842 postsynaptic early endosome
Cellular Component GO:0030904 retromer complex
Cellular Component GO:0097422 tubular endosome
Molecular Function GO:0034452 dynactin binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0034713 type I transforming growth factor beta receptor binding
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.