Search Results
Overview
| Uniprot ID | A0A5G2QPX2 |
|---|---|
| Protein Name | Malate dehydrogenase |
| Gene Name | MDH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | MERKDLLKANVKIFK |
| 119 | DLLKANVKIFKCQGA |
| 122 | KANVKIFKCQGAALD |
| 130 | CQGAALDKYAKKSVK |
| 137 | KYAKKSVKVIVVGNP |
| 154 | TNCLTASKSAPSIPK |
| 161 | KSAPSIPKENFSCLT |
| 176 | RLDHNRAKAQIALKL |
| 211 | YPDVNHAKVKLQAKE |
| 217 | AKVKLQAKEVGVYEA |
| 248 | QRGAAVIKARKLSSA |
| 251 | AAVIKARKLSSAMSA |
| 260 | SSAMSAAKAICDHVR |
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)
Protein Sequence
10
MTRGHHFELF
20
GLYSEPIRVL
30
VTGAAGQIAY
40
SLLYSIGNGS
50
VFGKDQPIIL
60
VLLDITPMMG
70
VLDGVLMELQ
80
DCALPLLKDV
90
IATDKEEIAF
100
KDLDVAILVG
110
SMPRRDGMER
120
KDLLKANVKI
130
FKCQGAALDK
140
YAKKSVKVIV
150
VGNPANTNCL
160
TASKSAPSIP
170
KENFSCLTRL
180
DHNRAKAQIA
190
LKLGVTSDDV
200
KNVIIWGNHS
210
STQYPDVNHA
220
KVKLQAKEVG
230
VYEAVKDDSW
240
LKGEFITTVQ
250
QRGAAVIKAR
260
KLSSAMSAAK
270
AICDHVRDIW
280
FGTPEGEFVS
290
MGIISDGNSY
300
GVPDDLLYSF
310
PVTIKDKTWK
320
IVEGLPINDF
330
SREKMDLTAK
340
ELAEEKETAF
EFLSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0047995 | (2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity |
| Molecular Function | GO:0030060 | L-malate dehydrogenase (NAD+) activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.