Overview
| Uniprot ID | A0A5G2QQ15 |
|---|
| Protein Name | DNA-directed RNA polymerase subunit |
|---|
| Gene Name | POLR2G |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 144 |
QDDEIRLKIVGTRVD |
| 73 |
VLYPVKYKAIVFRPF |
Function
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA
Protein Sequence
10
MFYHISLEHE
20
ILLHPRYFGP
30
NLLNTVKQKL
40
FTEVEGTCTG
50
KYGFVIAVTT
60
IDNIGAGVIQ
70
PGRGFVLYPV
80
KYKAIVFRPF
90
KGEVVDAVVT
100
QVNKVSPSTG
110
ANPMSPSFQS
120
IPSEMEFDPN
130
SNPPCYKTMD
140
EDIVIQQDDE
150
IRLKIVGTRV
160
DKNDIFAIGS
170
LMDDYLGECL
180
LMHHATVVAL
190
RRVCGGRGWT
200
WDLILESPMK
210
ETLWLSARKI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000428 |
DNA-directed RNA polymerase complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0006352 |
DNA-templated transcription initiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.