Search Results

Overview

Uniprot ID	A0A5G2QQ26
Protein Name	Cyclin-G-associated kinase
Gene Name	GAK
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
216	GQLVEFLKKVESKGP

Function

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly

Protein Sequence

10 MSLLQSALDF 20 LAGPGSLGGA 30 AGRDQTDFVG 40 QTVEMGELRL 50 RVRRVLAEGG 60 FAFVYEAQDL 70 GSGREYALKR 80 LLSNEEEKNR 90 VIIQEVCFMV 100 SFSGERSFLL 110 CASLSGPRAL 120 GSRASVPGLL 130 FSVSKLCPLR 140 ACRPPGPPCP 150 SHLRVRCALG 160 LPSRRPLVRL 170 MHSPLTRHLQ 180 KKLSGHPNIV 190 QFCSAASIGK 200 EESDTGQAEF 210 LLLTELCKGQ 220 LVEFLKKVES 230 KGPLSCDTVL 240 KIFYQTCRAV 250 QHMHKQKPPI 260 IHRDLKVENL 270 LLSNQGTIKL 280 CDFGSATTIS 290 HYPDYSWSAQ 300 QRALVEEEIT 310 RNTTPMYRTP 320 EIVDLYSNFP 330 IGEKQDIWAL 340 GCILYLLCFR 350 QHPFEDGAKL 360 RIVNGKYVIP 370 PDDTRYSVFH 380 GLIRATLKVN 390 PEERLSITEL 400 VNQLQEIAAA 410 RNVNPKSPIT 420 ELLEQNGGCG 430 SAAPPTGSAS 440 SGCSGGLAVA 450 EYDQPYGGLL 460 DILRGGTERL 470 FTNIKDTSSK 480 VIQSVASYAK 490 GDLDISYITS 500 RIAVMSFPAE 510 GVESAIKNNV 520 EDVRLFLDSK 530 HPGRYTVYNL 540 SPRTYRPSRF 550 HSRVSECGWV 560 ARRAPSLHSL 570 YSLCRSMHAW 580 LRQDPKNVCV 590 VHCMDGRAAS 600 AVAVCSFLCF 610 CRLFSTAEAA 620 VYMFSMKRCP 630 PGIWPSHKRY 640 IEYVCDMVAE 650 EPITPHSKPV 660 LVKAVAMTPV 670 PLFSKQRHGC 680 RPFCEVYVGD 690 ERVATTSQEY 700 DKMRDFRVED 710 GKAVIPLDVA 720 VQGDVLVVIY 730 HARSTLGGRL 740 QAKMASMKMF 750 QIQFHTGFVP 760 RNATTVKFAK 770 YDLDACDIQE 780 KFPDLFQVHL 790 EVEVEPRDRP 800 SREAPPWESA 810 SMRGLNPKIL 820 FSSREEQQDV 830 LSKFGKPELP 840 RQPGSTAQYE 850 AEGPGPDLPH 860 SSADANHFLH 870 TLDWQEDRDT 880 TAGPEGHPAK 890 EDPPAAAEDG 900 RESEPSDEEA 910 TTLSAESGDT 920 ADEDAPGPAA 930 PPEDSVDLLG 940 LHAEAGPAPC 950 PQARGGPPSN 960 ADLLSCLLGA 970 PPPAPAGTTG 980 RLLEGDTSLL 990 FSSPAPPPSA 1000 PTAPREASAP 1010 AADPFDPLLL 1020 PSDPVSQPCS 1030 RPDLFGEFLT 1040 SDSPAGPPAS 1050 FPSTHSAPPP 1060 ACSSDFLRLG 1070 DLPTEPSRVT 1080 ASTSHPDLLG 1090 GWDAWAEASA 1100 PTSATEGPFF 1110 SPGGQPAPPG 1120 PPASQPQSQN 1130 QDPFADLGDL 1140 SSSLQGSPAA 1150 PPPGGFGPKT 1160 GALPKASGSW 1170 QTSRPSAQGT 1180 SWHPQARPPP 1190 KATAQPRPNY 1200 TPGFSVIGSR 1210 EERGVRAPGF 1220 GPRPRVSEND 1230 FEDLLSSQGF 1240 SSRADRRGPR 1250 TVAEMRRQDQ 1260 ARDTDPLKLK 1270 LQDWTEGKER 1280 NIRALLSTLH 1290 TVLWDGESRW 1300 TPVGMADLVT 1310 PGQVKKQYRR 1320 AVLVVHPDKA 1330 QGQPYEQHAR 1340 LIFMELSDAW 1350 AEFESQGCRP LF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030136	clathrin-coated vesicle
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0031982	vesicle
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0030276	clathrin binding
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Biological Process	GO:0048268	clathrin coat assembly
Biological Process	GO:0072318	clathrin coat disassembly
Biological Process	GO:0072583	clathrin-dependent endocytosis
Biological Process	GO:0007030	Golgi organization
Biological Process	GO:0090160	Golgi to lysosome transport
Biological Process	GO:0010977	negative regulation of neuron projection development
Biological Process	GO:0034067	protein localization to Golgi apparatus
Biological Process	GO:0072659	protein localization to plasma membrane
Biological Process	GO:1905443	regulation of clathrin coat assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.