Search Results
Overview
| Uniprot ID | A0A5G2QQ72 |
|---|---|
| Protein Name | Erlin |
| Gene Name | ERLIN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 237 | LMESEKTKLLIAAQK |
| 244 | KLLIAAQKQKVVEKE |
| 332 | YLQLMKYKAIASNSK |
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex
Protein Sequence
10
MAQLGAVVAV
20
AASFFCASLF
30
SAVHKIEEGH
40
IGVYYRGGAL
50
LTSTSGPGFH
60
LMLPFITSYK
70
SVQTTLQTDE
80
VKNVPCGTSG
90
GVMIYFDRIE
100
VVNFLVPHAG
110
TSLSLQSHTH
120
THRPQHQAPR
130
EGTVAVSQNT
140
VSPSLLVLSL
150
SFLSVYDIVK
160
NYTADYDKAL
170
IFNKIHHELN
180
QFCSVHTLQE
190
VYIELFDQID
200
ENLKLALQQD
210
LTSMAPGLVI
220
QAVRVTKPNI
230
PEAIRRNYEL
240
MESEKTKLLI
250
AAQKQKVVEK
260
EAETERKKAL
270
IEAEKVAQVA
280
EITYGQKVME
290
KETEKKISEI
300
EDAAFLAREK
310
AKADAECYTA
320
MKIAEANKLK
330
LTPEYLQLMK
340
YKAIASNSKI
350
YFGKDIPNMF
360
MDSAGSLGKQ
370
FEGLTDKLSF
380
GLEDEPLEAG
TEEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0045541 | negative regulation of cholesterol biosynthetic process |
| Biological Process | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| Biological Process | GO:0032933 | SREBP signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.