Search Results
Overview
| Uniprot ID | A0A5G2QQG7 |
|---|---|
| Protein Name | Switch-associated protein 70 |
| Gene Name | SWAP70 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 272 | LPDRDGKKCLFLIKC |
| 29 | DHSGKVSKSQLKVLS |
| 291 | FEISASDKKKKQEWI |
| 329 | RRKELRKKLLAEQEE |
| 80 | LNKFILEKVQDNFDK |
| 87 | KVQDNFDKIEFNRMC |
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion
Protein Sequence
10
MGVLKDELLK
20
AIWHAFTALD
30
LDHSGKVSKS
40
QLKVLSHNLC
50
TVLKVPHDPV
60
ALEEHFRDDD
70
EGPVSNQGYM
80
PYLNKFILEK
90
VQDNFDKIEF
100
NRMCWTLCVK
110
KNLTKSPLLI
120
TEDDAFKIWV
130
IFNFLSEDKY
140
PLVIVPEEIE
150
YLLKKLTEAM
160
GGGWQQEQFE
170
HYKINFDDSK
180
DGLSAWELIE
190
LIGNGQFSKG
200
MDRQTVSMAI
210
NEVFNELILD
220
VLKQGYMMKK
230
GHRRKNWTER
240
WFVLKPNIIS
250
YYVSEDLKDK
260
KGDILLDENC
270
CVESLPDRDG
280
KKCLFLIKCF
290
DKTFEISASD
300
KKKKQEWIQA
310
IQSTIHLLKL
320
GSPPPHKEAR
330
QRRKELRKKL
340
LAEQEELERQ
350
MKELQVANEN
360
KQQELEAVRK
370
KLEEAASRAA
380
EEEKKRLQTQ
390
VELQARFSTE
400
LEREKLIRQQ
410
MEEQVAQKSS
420
ELEQYLQRVR
430
ELEDMYLKLQ
440
EALEDERQAR
450
QDEETVRKLQ
460
ARLLEEESSK
470
RAELEKWHLE
480
QQQAIRTTEA
490
EKQELENQRV
500
IKEQALQEAM
510
EQLQQLELER
520
KQALEQYEGV
530
KKKLELATNK
540
TKSWKDKVAQ
550
HEGLIRLIEP
560
GSKNPHLITN
570
WGPAAFTQAE
580
LEEREKSWKG
KKTTE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003677 | DNA binding |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0030835 | negative regulation of actin filament depolymerization |
| Biological Process | GO:0033633 | negative regulation of cell-cell adhesion mediated by integrin |
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0060754 | positive regulation of mast cell chemotaxis |
| Biological Process | GO:0032880 | regulation of protein localization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.