Search Results

Overview

Uniprot IDA0A5G2QQH9
Protein NameNAD-dependent protein deacetylase sirtuin-2
Gene NameSIRT2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
215 TLGWMKEKIFSEVTP

Function

No function data available.

Protein Sequence

10 TVPSLPNPAS 20 GAWLPRPHPF 30 QDSDSDSDTE 40 EGAAGGEAEM 50 DFLRNFFSQT 60 LGLGTQKERL 70 LDELTLEGVS 80 RYMQSERCRR 90 VICLVGAGIS 100 TCNRGIPDFR 110 SPSTGLYANL 120 EKYRLPYPEA 130 IFEIGYFKKH 140 PEPFFALAKE 150 LYPGQFKPTI 160 CHYFIRLLKE 170 KGLLLRCYTQ 180 NIDTLERVAG 190 LEPEDLVEAH 200 GTFYTSHCIS 210 PLCRQEYTLG 220 WMKEKIFSEV 230 TPKCEKCQSV 240 VKPDIVFFGE 250 NLPARFFSCM 260 QSDFLKVDLL 270 IVMGTSLQVQ 280 PFASLISKAP 290 LSTPRLLINK 300 EKTGQTDPFL 310 GMMMGLGGGM 320 DFDSKKAYRD 330 VAWLGDCDQG 340 CLALADLLGW 350 KKELEDLVRK 360 EHASIDAQSG 370 SGTPNPTTSA 380 SPRKSPPPAK 390 AEARTSEGEK PQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005814 centriole
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0000183 rDNA heterochromatin formation
Biological Process GO:0031641 regulation of myelination
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030426 growth cone
Cellular Component GO:0072687 meiotic spindle
Cellular Component GO:0005874 microtubule
Cellular Component GO:0030496 midbody
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0033010 paranodal junction
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0043220 Schmidt-Lanterman incisure
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0035035 histone acetyltransferase binding
Molecular Function GO:0140228 histone benzoyllysine debenzoylase activity
Molecular Function GO:0017136 histone deacetylase activity, NAD-dependent
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0046970 histone H4K16 deacetylase activity, NAD-dependent
Molecular Function GO:0140219 histone methacryllysine demethacrylase activity
Molecular Function GO:0070403 NAD+ binding
Molecular Function GO:0003950 NAD+ poly-ADP-ribosyltransferase activity
Molecular Function GO:0140773 NAD-dependent protein demyristoylase activity
Molecular Function GO:0140774 NAD-dependent protein depalmitoylase activity
Molecular Function GO:0042903 tubulin deacetylase activity
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051301 cell division
Biological Process GO:0061433 cellular response to caloric restriction
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0022011 myelination in peripheral nervous system
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0045843 negative regulation of striated muscle tissue development
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:1900119 positive regulation of execution phase of apoptosis
Biological Process GO:0045723 positive regulation of fatty acid biosynthetic process
Biological Process GO:0045836 positive regulation of meiotic nuclear division
Biological Process GO:1900195 positive regulation of oocyte maturation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.