Search Results
Overview
| Uniprot ID | A0A5G2QQJ2 |
|---|---|
| Protein Name | Negative elongation factor E |
| Gene Name | NELFE |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | KKALLALKKQSSSST |
| 34 | KALLALKKQSSSSTA |
Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA
Protein Sequence
10
MLVIPPGLSE
20
EEEALQKKFN
30
KLKKKKKALL
40
ALKKQSSSST
50
ASQGGVKRSL
60
SEQPVVDTAT
70
ATEQAKQLVK
80
SGAISAIKAE
90
TKNSGFKRSR
100
TLEGKLKDPE
110
KGPVPTFQPF
120
QRSISADDDL
130
QESSRRPQRK
140
SLYESFVSSS
150
DRLRELGPDG
160
EEAEGPGAGD
170
GPPRSFDWGY
180
EERGSARSST
190
SPPRSRSRDR
200
SRERNRDRDR
210
ERDRDRDRDR
220
DRDRDRDRDR
230
DRDRDRDRDR
240
DRDRDRDRDR
250
EGPFRRSDSF
260
PERRAPRKGN
270
TLYVYGEDMT
280
PTLLRGAFSP
290
FGNIIDLSMD
300
PPRNCAFVTY
310
EKMESADQAV
320
AELNGTQVES
330
VQLKVSIARK
340
QPMLDAATGK
350
SVWGSLAVQN
360
SPKGCHRDKR
370
TQIVYSDDVY
KENLVDGF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0032021 | NELF complex |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003746 | translation elongation factor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.