Overview
| Uniprot ID | A0A5G2QQK9 |
|---|
| Protein Name | Eukaryotic translation initiation factor 3 subunit M |
|---|
| Gene Name | EIF3M |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 144 |
TELDQVRKWISDWNL |
| 155 |
DWNLNTEKKHTLLRL |
| 171 |
YEALVDCKKSDAASK |
| 208 |
RCIVRALKDPNAFLF |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression
Protein Sequence
10
RSVPLPLRKA
20
AELRAYLKSK
30
GAEISEENSE
40
GGLHVDLAQI
50
IEACDVCLKE
60
DDKDVESVMN
70
SVVSLLLILE
80
PDKQEALIES
90
LCEKLVKFRE
100
GERPSLRLQL
110
LSNLFHGMDK
120
NTPVRYTVYC
130
SLIKVAASCG
140
AIQYIPTELD
150
QVRKWISDWN
160
LNTEKKHTLL
170
RLLYEALVDC
180
KKSDAASKVM
190
VELLGSYTED
200
NASQARVDAH
210
RCIVRALKDP
220
NAFLFDHLLT
230
LKPVKFLEGE
240
LIHDLLTIFV
250
SAKLASYVKF
260
YQNNKDFIDS
270
LGLLHEQNMA
280
KMRLLTFMGM
290
AVENKEISFD
300
TMQQELQIGA
310
DDVEAFVIDA
320
VRTKMVYCKI
330
DQTQRKVVVS
340
HSTHRTFGKQ
350
QWQQLYDTLN
360
AWKQNLNKVK
NSLLSLSDT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016282 |
eukaryotic 43S preinitiation complex |
| Cellular Component |
GO:0033290 |
eukaryotic 48S preinitiation complex |
| Cellular Component |
GO:0071541 |
eukaryotic translation initiation factor 3 complex, eIF3m |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Biological Process |
GO:0001732 |
formation of cytoplasmic translation initiation complex |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.