Search Results
Overview
| Uniprot ID | A0A5G2QQU9 |
|---|---|
| Protein Name | Profilin |
| Gene Name | PFN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | ALVIVMGKEGVHGGT |
| 91 | CTMDIRTKSQGGEPT |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG
Protein Sequence
10
MAGWQSYVDN
20
LMCDGCCQEA
30
AIVGYCDAKY
40
VWAATAGGVF
50
QSITPVEIDM
60
IVGKDREGFF
70
TNGLTLGAKK
80
CSVIRDSLYV
90
DGDCTMDIRT
100
KSQGGEPTYN
110
VAVGRAGRAL
120
VIVMGKEGVH
130
GGTLNKKAYE
140
LALYLRRYPN
150
ITIWSVSSLF
160
FIGPIFICSL
170
SFYMKLHYCG
180
LGCLVMNFFF
ICILCHTIV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.