Search Results
Overview
| Uniprot ID | A0A5G2QQW0 |
|---|---|
| Protein Name | Calcium uniporter protein |
| Gene Name | MCU |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | TYHVRPPKRDLLSHE |
| 185 | IERLEDLKEQLAPLE |
| 193 | EQLAPLEKVRIEISR |
| 290 | KSRFDLEKYNQLKDA |
Function
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways
Protein Sequence
10
QCCSSCGSGH
20
CYGTDLIPDP
30
GTLHVHQRLS
40
SWQNLGVVYC
50
STVVPSDDVT
60
VVYQNGLPVI
70
SVRLPSRRER
80
CQFTLKPISD
90
SVGVFLRQLQ
100
EEDRGIDRVA
110
IYSPDGVRVA
120
ASTGIDLLLL
130
DDFKLVINDL
140
TYHVRPPKRD
150
LLSHENAATL
160
NDVKTLVQQL
170
YTTLCIEQHQ
180
LNKERELIER
190
LEDLKEQLAP
200
LEKVRIEISR
210
KAEKRTTLVL
220
WGGLAYMATQ
230
FGILARLTWW
240
EYSWDIMEPV
250
TYFITYGSAM
260
AMYAYFVMTR
270
QEYVYPEARD
280
RQYLLFFHKG
290
AKKSRFDLEK
300
YNQLKDAIAQ
310
AEMDLKRLRD
320
PLQVHLPLRQ
IGEKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990246 | uniplex complex |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0015292 | uniporter activity |
| Biological Process | GO:0036444 | calcium import into the mitochondrion |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0072732 | cellular response to calcium ion starvation |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0051560 | mitochondrial calcium ion homeostasis |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0051561 | positive regulation of mitochondrial calcium ion concentration |
| Biological Process | GO:0090141 | positive regulation of mitochondrial fission |
| Biological Process | GO:0090023 | positive regulation of neutrophil chemotaxis |
| Biological Process | GO:0051259 | protein complex oligomerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.