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Overview

Uniprot IDA0A5G2QR85
Protein NameProbable ATP-dependent RNA helicase DDX23
Gene NameDDX23
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
634 VYIGSAGKPHERVEQ

Function

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA

Protein Sequence

10 MAGELADKKD 20 RDASPSKDER 30 KRSRTPDRER 40 DRDRDRKSSP 50 SKDRKRHRSR 60 DRRRGGSRSR 70 SRSRSKSTER 80 DRRHKERERD 90 KERDRNKKDR 100 DRDKDGHRRD 110 KDRKRSSLSP 120 GRGKDFKSRK 130 DRDFKKDEED 140 EHGDKKPKAQ 150 PLSLEELLAK 160 KKAEEEAEAK 170 PKFLSKAERE 180 AEALKRRQQE 190 VEERQRMLEE 200 ERKKRKQFQD 210 LGRKMLEDPQ 220 ERERRERRER 230 MERETNGNED 240 EEGRQKIREE 250 KDKSKELHAI 260 KERYLGGIKK 270 RRRTRHLNDR 280 KFVFEWDASE 290 DTSIDYNPLY 300 KERHQVQLLG 310 RGFIAGIDLK 320 QQKREQSRFY 330 GDLMEKRRTL 340 EEKEQEEARL 350 RKLRKKEAKQ 360 RWDDRHWSQK 370 KLDEMTDRDW 380 RIFREDYSIT 390 TKGGKIPNPI 400 RSWKDSSLPP 410 HILEVIDKCG 420 YKEPTPIQRQ 430 AIPIGLQNRD 440 IIGVAETGSG 450 KTAAFLIPLL 460 VWITTLPKID 470 RIEESDQGPY 480 AIILAPTREL 490 AQQIEEETIK 500 FGKPLGIRTV 510 AVIGGISRED 520 QGFRLRMGCE 530 IVIATPGRLI 540 DVLENRYLVL 550 SRCTYVVLDE 560 ADRMIDMGFE 570 PDVQKILEHM 580 PVSNQKPDTD 590 EAEDPEKMLA 600 NFESGKHKYR 610 QTVMFTATMP 620 PAVERLARSY 630 LRRPAVVYIG 640 SAGKPHERVE 650 QKVFLMSESE 660 KRYYNACTLH 670 GGKGQEQREF 680 ALSNLKAGAK 690 DILVATDVAG 700 RGIDIQDVSM 710 VVNYDMAKNI 720 EDYIHRIGRT 730 GRAGKSGVAI 740 TFLTKEDSAV 750 FYELKQAILE 760 SPVSSCPPEL 770 ANHPDAQHKP 780 GTILTKKRRE ETIFA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003676 nucleic acid binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.