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Overview

Uniprot IDA0A5G2QSC2
Protein NameHeat shock protein 75 kDa, mitochondrial
Gene NameTRAP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
267 YVAQAPDKPRYTLHY
312 SVSLYSRKVLIQTKA
356 QESALIRKLQGVLQQ
39 EFQAETKKLLDIVAR
541 GSRVTNVKVTLRLDT
642 RLNRLLIKALERQ**

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Protein Sequence

10 MARELRTLLL 20 WGHRLRAPAL 30 AAARGGSVSK 40 HEFQAETKKL 50 LDIVARSLYS 60 EKEVFIRELI 70 SNASDALEKL 80 RHKLVSEGQT 90 LPEMEIHLQT 100 DSEKGTITIQ 110 DTGVGMTREE 120 LVSNLGTIAR 130 SGSKAFLDAL 140 QNQAEASGKI 150 IGQFGVGFYS 160 AFMVADKVEV 170 YSRSVDAGSP 180 GFQWLSDGSG 190 VFEIAEAAGV 200 RTGTKIIIHL 210 KADSREFAHE 220 ARVRDVVTKY 230 SNFVSFPLYL 240 NGRRLNTLQA 250 VWMMDPKDVS 260 EEQHEEFYRY 270 VAQAPDKPRY 280 TLHYKTDAPL 290 NIRSIFYVPE 300 MKPSVFDVSR 310 ELGPSVSLYS 320 RKVLIQTKAT 330 NILPTWLRFV 340 RGVVDSEDIP 350 LNLSRELLQE 360 SALIRKLQGV 370 LQQRLIKFFS 380 DQSKKDVEKY 390 ARFFEDYGLF 400 MREGIVTTTE 410 QEVKEDIAKL 420 LRYESSALPA 430 GQLTSLPDYA 440 SRMQAGTRSI 450 YYLCAPNRHL 460 AEHSPYYEAM 470 KQKNTEVLFC 480 YEQFDELTLL 490 HLREFDRKKL 500 ISVETDIVID 510 HYKEEKFEDS 520 SPAGDRLSEE 530 EMEDLMAWMR 540 NALGSRVTNV 550 KVTLRLDTHP 560 AMITVLEMGA 570 ARHFLRMQQL 580 AKTQEERAQL 590 LQPTLEINPR 600 HTLIKKLSQL 610 RHSEPDLAQL 620 LVDQIYENAM 630 ITAGLSDDPR 640 PMVSRLNRLL IKALERQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0051082 unfolded protein binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.