Search Results
Overview
| Uniprot ID | A0A5G2QSK4 |
|---|---|
| Protein Name | Rab GDP dissociation inhibitor |
| Gene Name | GDI2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | TEGSFVYKGGKIYKV |
| 195 | TFEGVDPKKTAMREV |
| 241 | CETINRIKLYSESLA |
| 300 | NGKVIGVKSEGEIAR |
| 309 | EGEIARCKQLICDPS |
| 319 | ICDPSYVKDRVEKVG |
| 324 | YVKDRVEKVGQVIRV |
| 391 | ASTTVETKEPEKEIR |
| 449 | ETTCDDIKDIYKRMT |
Function
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A
Protein Sequence
10
MNEEYDVIVL
20
GTGLTECILS
30
GIMSVNGKKV
40
LHMDRNPYYG
50
GESASITPLE
60
DLYKRFNIPG
70
APPASMGRGR
80
DWNVDLIPKF
90
LMANGKEWYY
100
LGNIAGAWGD
110
LMVGLSNRLN
120
YVTLTGQLVK
130
MLLFTEVTRY
140
LDFKVTEGSF
150
VYKGGKIYKV
160
PSTEAEALAS
170
SLMGLFEKRR
180
FRKFLVYVAN
190
FDENDPRTFE
200
GVDPKKTAMR
210
EVYKKFDLGQ
220
DVIDFTGHAL
230
ALYRTDDYLD
240
QPCCETINRI
250
KLYSESLARY
260
GKSPYLYPLY
270
GLGELPQGFA
280
RLSAIYGGTY
290
MLNKPIEEII
300
VQNGKVIGVK
310
SEGEIARCKQ
320
LICDPSYVKD
330
RVEKVGQVIR
340
VICILSHPIK
350
NTSDANSCQI
360
IIPQNQVNRK
370
SDIYVCMISS
380
AHNVAAQGKY
390
IAIASTTVET
400
KEPEKEIRPA
410
LELLEPIEQK
420
FVSISDLLVP
430
KDLGTDSQIF
440
ISRTYDATTH
450
FETTCDDIKD
460
IYKRMTGSEF
470
DFEEMKRKKN
DIYGED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Biological Process | GO:1902018 | negative regulation of cilium assembly |
| Biological Process | GO:1903565 | negative regulation of protein localization to cilium |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.