Search Results

Overview

Uniprot IDA0A5G2QSS3
Protein NameProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Gene NamePLOD1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
77 ASSGGGLKVRLLKKA

Function

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

Protein Sequence

10 MAGQLSLILM 20 SWGESKAGWP 30 RLSETVYNLL 40 VLTVATKETE 50 GFRRFKRSAQ 60 FFNYKIQALG 70 LGEDWNEKEA 80 SSGGGLKVRL 90 LKKALEKHAD 100 ENLVILFTDS 110 YDVVFASGPR 120 ELLKKFRQAK 130 SQVVFSAEEL 140 IYPDRRLEAK 150 YPAVSDGKRF 160 LGSGGFIGYA 170 PNLSKLVAEW 180 EGQDSDSDQL 190 FYTKIFLDPE 200 KRERINITLD 210 HRCRIFQNLD 220 GALDEVVLKF 230 EMGQVRARNL 240 AYDTLPVLIH 250 GNGPTKLQLN 260 YLGNYIPRFW 270 TFETGCSVCD 280 EGLRSLKGIG 290 DEALPTVLVG 300 LFIEQPTPFL 310 SLFFQRLLRL 320 QYPRKRMRLF 330 IHNHEQHHKA 340 LVEQFLAEHG 350 DEYQSVKLVG 360 PEVRVANADA 370 RNMGADLCRQ 380 DRSCTYYFSV 390 DADVALTEPK 400 TLRLLIEQNK 410 NVLAPLMTRH 420 GRLWSNFWGA 430 LSADGYYARS 440 EDYVDIVQGR 450 RVGVWNVPYI 460 SNVYLIKGSA 470 LRAELQQTDL 480 FHHSKLDPDM 490 AFCANIRQQD 500 VFMFLTNRHA 510 FGHLLSLDSY 520 QTTHLHNDLW 530 EVFSNPEDWK 540 EKYIHENYTK 550 ALAGKLVETP 560 CPDVYWFPIF 570 TETACDELVE 580 EMEHYGQWSL 590 GDNKDNRIQG 600 GYENVPTIDI 610 HMNQISFERE 620 WHKFLVEYIA 630 PMTEKLYPGY 640 YTRAQFDLAF 650 VVRYKPDEQP 660 SLMPHHDAST 670 FTINIALNRV 680 GVDYEGGGCR 690 FLRYNCSIRA 700 PRKGWTLMHP 710 GRLTHYHEGL 720 PTTKGTRYIA VSFVDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0030867 rough endoplasmic reticulum membrane
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0031418 L-ascorbic acid binding
Molecular Function GO:0008475 procollagen-lysine 5-dioxygenase activity
Biological Process GO:0032964 collagen biosynthetic process
Biological Process GO:0008544 epidermis development
Biological Process GO:0046947 hydroxylysine biosynthetic process
Biological Process GO:0001666 response to hypoxia

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.