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Overview

Uniprot IDA0A5G2QSU8
Protein Name26S proteasome regulatory subunit 6A
Gene NamePSMC3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
246 DSEIKIMKSEVLRVT
315 KGKCAVIKTSTRQTY
363 TEYDSRVKAMEVDER
401 LPMNHKEKFENLGIQ
435 RACAAQTKATFLKLA
466 RDAFALAKEKAPSII

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MKSPAFTEPT 20 PLDWLFLCLD 30 HSLPGPQNEG 40 RKEGTHGGVW 50 PSHPAPSLCL 60 LQDYEKALFF 70 PCKAAELVND 80 YGKGWSLKYR 90 AMSQYHMAVA 100 YRLLGHLGSA 110 MECCEESMKI 120 ALQHGDRPLQ 130 ALCLLCFADI 140 HRNRGDLETA 150 FPRYDSAMSI 160 MTEIGNRLGQ 170 VQSSAGVKKD 180 IINLSPRLLS 190 GLIFNLLLQE 200 MNLLPQLESP 210 VTRQEKMATV 220 WDEAEQDGIG 230 EEVLKMSTEE 240 IVQRTRLLDS 250 EIKIMKSEVL 260 RVTHELQAMK 270 DKIKENSEKI 280 KVNKTLPYLV 290 SNVIELLDVD 300 PNDQEEDGAN 310 IDLDSQRKGK 320 CAVIKTSTRQ 330 TYFLPVIGLV 340 DAEKLKPGDL 350 VGVNKDSYLI 360 LETLPTEYDS 370 RVKAMEVDER 380 PTEQYSDIGG 390 LDKQIQELVE 400 AIVLPMNHKE 410 KFENLGIQPP 420 KGVLMYGPPG 430 TGKTLLARAC 440 AAQTKATFLK 450 LAGPQLVQMF 460 IGDGAKLVRD 470 AFALAKEKAP 480 SIIFIDELDA 490 IGTKRFDSEK 500 AGDREVQRTM 510 LELLNQLDGF 520 QPNTQVKVIA 530 ATNRVDILDP 540 ALLRSGRLDR 550 KIEFPMPNEE 560 ARARIMQIHS 570 RKMNVSPDVN 580 YEELARCTDD 590 FNGAQCKAVC 600 VEAGMIALRR 610 GATELTHEDY 620 MEGILEVQAK KKANLQYYA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Cellular Component GO:0022624 proteasome accessory complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0043921 host-mediated perturbation of viral transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.