Search Results
Overview
| Uniprot ID | A0A5G2QSX9 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 2A |
| Gene Name | EIF2A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | AVYVPGSKGAPSFVR |
| 289 | VWDVKNYKLISKPVA |
Function
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner
Protein Sequence
10
MAPSAPLLTV
20
RGSEGLYLVN
30
GPPHFTESTV
40
FPRESGKNCK
50
AYTFSKDGTL
60
FAWGNGERIN
70
VINVTTKELL
80
HSFDLPKAVC
90
LEFSPKNTIL
100
ATWQPYTNTI
110
ANKLHLKKIN
120
DFVLSPGPQP
130
YKVAVYVPGS
140
KGAPSFVRLY
150
QYPNFDGPHA
160
ALANKSFFKA
170
DKVTMLWNKK
180
ATAVLVIAST
190
EVDKTGASYY
200
GEQTLHYIAT
210
NGESAVVQLP
220
KNGPIYDVVW
230
NSSSTEFCAV
240
YGFMPAKATI
250
FNLKCDPVFD
260
FGTGPRNAAY
270
YSPHGHILVL
280
AGFGNLRGQM
290
EVWDVKNYKL
300
ISKPVASDST
310
YFAWCPDGEH
320
ILTATCAPRL
330
RVNNGYKIWH
340
YTGSVLHKYD
350
VPSNAELWQV
360
SWQPFLDGIF
370
PEKSITYQAV
380
PSDVPSEEPK
390
VATAYRPPAL
400
RNKPVTNSKL
410
HEEEPPQNMK
420
PQPGNEKPLS
430
KTALKNQRKH
440
EAKKAAKQEA
450
RSDKSPDMAP
460
SPAPQNTPRN
470
TVSHSTSGDP
480
EIDKKIKNLK
490
KKLKAIEQLK
500
EQAATGKQLE
510
KNQLEKIQKE
520
KALLQELEDL
ELGI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0043022 | ribosome binding |
| Biological Process | GO:0006417 | regulation of translation |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Molecular Function | GO:0000049 | tRNA binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.