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Overview

Uniprot IDA0A5G2QT51
Protein NameVesicle-fusing ATPase
Gene NameNSF
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
107 EIDFLQKKSIDSNPY
256 QMGCKHVKGILLYGP
641 KAPPQGRKLLIIGTT
710 KKVWIGIKKLLMLIE
730 DPEYRVRKFLALLRE

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin

Protein Sequence

10 MGGRNGNMQA 20 ARCPTDELSL 30 SNCAVVNEKD 40 FQSGQHVVVR 50 TSPNHRYTFT 60 LRTHPSVVPG 70 SIAFSLPQRK 80 WAGLSIGQEI 90 EVSSYTFDKA 100 KQCIGTMTME 110 IDFLQKKSID 120 SNPYDTDKMA 130 AEFIQQFNNQ 140 AFSVAQQLVF 150 SFNEKLFGLL 160 VKDIEAMDPS 170 ILKGEPGTGK 180 RQKIEVGLVV 190 GNSQVAFEKA 200 ENSSLNLIGK 210 AKTKENRQSI 220 INPDWNFEKM 230 GIGGLDKEFS 240 DIFRRAFASR 250 VFPPEIVEQM 260 GCKHVKGILL 270 YGPPGCGKTL 280 LARQIGKMLN 290 AREPKVVNGP 300 EILNKYVGES 310 EANIRKLFAD 320 AEEEQRRLGA 330 NSGLHIIIFD 340 EIDAICKQRG 350 SMAGSTGVHD 360 TVVNQLLSKI 370 DGVEQLNNIL 380 VIGMTNRPDL 390 IDEALLRPGR 400 LEVKMEIGLP 410 DEKGRLQILH 420 IHTARMRGHQ 430 LLSADVDIKE 440 LAVETKNFSG 450 AELEGLVRAA 460 QSTAMNRHIK 470 ASTKVEVDME 480 KAESLQVTRG 490 DFLASLENDI 500 KPAFGTNQED 510 YASYIMNGII 520 KWGDPVTRVL 530 EDGELLVQQT 540 KNSDRTPLVS 550 VLLEGPPHSG 560 KTALAARIAE 570 ESNFPFIKIC 580 SPDKMIGFSE 590 TAKTVDAEKS 600 ECLEYVHIYI 610 EFLNNNNASL 620 PDYVPIGPRF 630 SNLVLQALLV 640 LLKKAPPQGR 650 KLLIIGTTSR 660 KDVLQEMEML 670 NAFSTTIHVP 680 NIATGEQLLE 690 ALELLGNFKD 700 KERTTIAQQV 710 KGKKVWIGIK 720 KLLMLIEMSL 730 QMDPEYRVRK 740 FLALLREEGA 750 SPLDFENELF SNAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0015031 protein transport
Biological Process GO:0035494 SNARE complex disassembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.