Search Results

Overview

Uniprot ID	A0A5G2QTJ6
Protein Name	Progranulin
Gene Name	GRN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
135	QHLGVPCKTKAQCPP
390	KGHTCVGKGHCKRKK
475	VKARTCEKEEDSALP

Function

Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8

Protein Sequence

10 MCSGQHLCSR 20 VYTRRKLNLR 30 PHTFLPAWMG 40 YSWGDSGSLG 50 AGAWGWGSDW 60 LQREGPSELK 70 LVAKSLLLFC 80 RWTMWTLVSW 90 VALVTGLVAG 100 TQCPDGQLCP 110 VACCLDPGGA 120 SYSCCNPVPD 130 KWPKALSQHL 140 GVPCKTKAQC 150 PPGHSCILTT 160 NETSNCCPFP 170 EAVSCRDGLH 180 CCPQGFHCSA 190 DGWSCLRRPD 200 TKPSDDILCP 210 NSQFHCPNSS 220 TCCTMLDGSW 230 GCCPMPQASC 240 CGDKVHCCPH 250 GTSCDLAHSR 260 CLTVTNTHPM 270 AKIPSQETIK 280 TAVWPLLPGL 290 QGHWQSPRLT 300 PALTQATCCS 310 DHIHCCPHGF 320 VCDPVKKKCF 330 SKENEAIDFF 340 TKLPAHSVQE 350 VKCDTEVSCP 360 DDYTCCRLQS 370 GKWGCCPFVQ 380 AVCCSDHQYC 390 CPKGHTCVGK 400 GHCKRKKDMV 410 TGLNKMPTRR 420 ASASQPGNTT 430 GCDQHTSCPV 440 GQTCCPSLSK 450 GWACCQLPHA 460 VCCEDRQHCC 470 PAGYTCNVKA 480 RTCEKEEDSA 490 LPATHLARVG 500 DVACGERRFC 510 HNNYTCCRDS 520 LGGWACCPYR 530 QGICCADGRH 540 CCPAGFRCGA 550 RGTKCLHKEA 560 LRWDAPLRDP APRQLL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005764	lysosome
Molecular Function	GO:0005125	cytokine activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.