Search Results
Overview
| Uniprot ID | A0A5G2QTQ6 |
|---|---|
| Protein Name | Diablo IAP-binding mitochondrial protein |
| Gene Name | DIABLO |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | RSHIQLVKSQVQEVR |
| 158 | EVRQLSQKAETKLAE |
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases
Protein Sequence
10
MRIMFFTWLK
20
NVCVFQKSEP
30
HSLSNDALMR
40
RAVSLVTDST
50
STFLSQTTYA
60
LIEAITEYTK
70
AVYTLISLYR
80
QYTSLLGKMN
90
SQEEDEVWQV
100
IIGARVEMTS
110
KQQEYLKLET
120
TWMTAVSLSE
130
MAAEAAYQTG
140
ADQASITARS
150
HIQLVKSQVQ
160
EVRQLSQKAE
170
TKLAEAQTEE
180
LRQKTQEEGH
190
ESAEPEQEAY
LRED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Biological Process | GO:0097193 | intrinsic apoptotic signaling pathway |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.