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Overview

Uniprot IDA0A5G2QTX5
Protein NameCondensin complex subunit 1
Gene NameNCAPD2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
100 KGRKARAKSAHGFDW
160 NPTISHQKNRPTREA

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size

Protein Sequence

10 MLEHFDTIYS 20 ILHHFRSIDP 30 GLKEDTLEFL 40 IKVVSRHSQE 50 LPTILDDAAL 60 SVSDRSAHLN 70 ALKMNCYALI 80 RLLESFETMT 90 SQTSLMDLDL 100 SGKGRKARAK 110 SAHGFDWEEE 120 RQPILQLLTQ 130 LLQLDIRHLW 140 NHSIIEEEFI 150 SLVTGCCYRL 160 LENPTISHQK 170 NRPTREAITC 180 LLGVALTRYN 190 HMLSATVKII 200 QMLQHFEHLA 210 SVLVAAVSLW 220 ATDYGMKSIV 230 GEIVREIGQK 240 CPQELSRDPS 250 GAKGFATFLT 260 ELAERVPAIL 270 MSSICILLDH 280 LDGENYMMRN 290 AVLAAMAEMV 300 LQVLNGDQLE 310 AAARDTRDQF 320 LDTLQAHGHD 330 VNSFVRSRVL 340 QLFTRIVQQK 350 ALPLTRFQAV 360 VALAVGRLAD 370 KSVLVCKNAI 380 QLLASFLANN 390 PFSCKLSDTD 400 LAGPLQKETQ 410 KLQEMRAQRR 420 AAAASTVLDP 430 EDEWEAMLPE 440 LKATLQQLLK 450 LPQEGEGMPE 460 EIAETETAKE 470 VESRIRQLLA 480 KASYRQAIIL 490 AREAIGHFQE 500 SQPFCHMDPE 510 DSEETRFLTL 520 LGTIFKGPEA 530 PTQEKTPQGA 540 VGNLGSGETG 550 CEDQSAPEKH 560 REDDELVKQE 570 MLVQYLQDAY 580 SFSQKITEAI 590 GIISKMMYEH 600 TTTVVQEVIE 610 FFVMVFQFGV 620 PQALFGVRRM 630 LPLIWSKEPG 640 VREAVLNAYR 650 QLYLKPKGDS 660 ARAKAQTLIH 670 NLSLLLVDAS 680 VGTIQCLEEI 690 LCEFVQKDEL 700 KPAVTQVLWE 710 RATEKVPCSP 720 LERCSSVMLL 730 GMMARGKPEI 740 VGSNLDTLVS 750 IGLDEKFPPD 760 YRLAQQVCHA 770 ITNISDRRKP 780 SLGKRHPPFR 790 LPQEHCLFER 800 LREMVTKGIV 810 HPDPLWIPFK 820 EAAVTLIYQL 830 AEGPEAICAQ 840 MLQGCAKQAL 850 EKLEEKSPPQ 860 EAPKDTPMLP 870 TFLLMNLLSL 880 AGDVALQQLV 890 HLEQAVSGEL 900 CRRRVLQEEQ 910 EHKAKDPKEK 920 DASSEATMEE 930 EMGLVGATAD 940 DTEAELIRGI 950 CKQTLAAFVP 960 LLLKVCNNPG 970 LYSNPELCAA 980 ASLALGKFCM 990 ISATFCDSQL 1000 RLLFTMLEKS 1010 SLPIVRSNLM 1020 IATGDLAIRF 1030 PNLVDPWTPH 1040 LYARLRDPAQ 1050 QVRKTAGLVM 1060 THLILKDMVK 1070 VKGQVSEMAV 1080 LLIDPAPQIA 1090 ALAKNFFNEL 1100 SHKGNAIYNL 1110 LPDIISRLSA 1120 PEGGVEEEPF 1130 HTIMKQLLSY 1140 ITKDKQTESL 1150 VEKLCQRFRT 1160 ARTERQYRDL 1170 AYCVSQLPLT 1180 ERGLRKMLDN 1190 FDCFGDKLSD 1200 ESIFSAFLSV 1210 VGKLRRGAKP 1220 EGKAVIDEFE 1230 QKLRACHTRG 1240 LDAIEEFEMG 1250 QGGSQRAPSA 1260 KKLPAVSRHR 1270 HLASAASDDD 1280 FVTPEPRRTT 1290 RRHPNTQQQV 1300 SKKKLRIVFS 1310 SDESSEEELS 1320 AEMMEDETPK 1330 KTTPIRRASA HRQRS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0051301 cell division
Biological Process GO:0007076 mitotic chromosome condensation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.