Search Results
Overview
| Uniprot ID | A0A5G2QTY6 |
|---|---|
| Protein Name | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase |
| Gene Name | PAICS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | IATGSFLKRNPGVKE |
| 81 | IKTAFTRKCGETAFI |
Function
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway
Protein Sequence
10
MQTRLGVLNI
20
GKKLYEGKTK
30
EVYELLDSPG
40
KVLLQSKDQI
50
TAGNAARKNH
60
LEGKAAISNT
70
ITSCVFQLLQ
80
EAGIKTAFTR
90
KCGETAFIAP
100
KCEMIPIEWV
110
CRRIATGSFL
120
KRNPGVKEGY
130
KFYPPKVEMF
140
FKDDANNDPQ
150
WSEEQLIAAN
160
FCFAGLVIGQ
170
TEVDVMSHAT
180
QAIFEILEKS
190
WLPQNCTLVD
200
MKVQIQWRFE
210
KIVLADVIDN
220
DSWRLWPSGD
230
RSQQKDKQSY
240
RDLKEVTPEG
250
LQMVKKNFEW
260
VAERVELLLK
270
TESQCRVVVL
280
MGSTSDLSHC
290
EKIKKACGNF
300
GIPCELRVTS
310
AHKGPDETLR
320
IKAEYEGDGI
330
PTVFVAVAGR
340
SNGLGPVMSG
350
NTAFPVISCP
360
PLSPDWGAQD
370
VWSSLRLPSG
380
LGCSTILSPE
390
GSAQFAAQIF
400
GLNNHLVWAK
410
LRANVLNTWI
420
SLKQADKKIR
EGNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004638 | phosphoribosylaminoimidazole carboxylase activity |
| Molecular Function | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| Biological Process | GO:0006189 | 'de novo' IMP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.