Search Results
Overview
| Uniprot ID | A0A5G2QUD2 |
|---|---|
| Protein Name | 3-hydroxyisobutyryl-CoA hydrolase |
| Gene Name | HIBCH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 76 | IMKGAGEKAFCAGGD |
| 92 | RVISENTKTNPKMVQ |
Function
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA
Protein Sequence
10
TCWCYSSFTQ
20
TMSKHTDAAA
30
EVLLERKGCA
40
GVITLNRPKF
50
LNALNLSMIQ
60
QIYPQLKKWE
70
QDPETFLIIM
80
KGAGEKAFCA
90
GGDIRVISEN
100
TKTNPKMVQD
110
FFREEYMLNN
120
AIDSCLKPYI
130
ALIHGITMGG
140
GVGLSVHGQF
150
RVATEKSLFA
160
MPETAIGLFP
170
DVGGGYFLPR
180
LQGKLGYFLA
190
LTGFRLKGRD
200
VYTAGIATHF
210
VDSEKLGMLE
220
DDLLALNSPS
230
KENIADVLET
240
YHTKSKIDQD
250
KSFILEEHMD
260
KINSWFSANT
270
VEEIIENLQQ
280
DGSSFALEQL
290
KVINKMSPTS
300
LKITLRQLME
310
GSSKTLPEVL
320
TMEYRLSQAC
330
IGGHDFHEGV
340
RAVLIDKDQN
350
PKWKPANLKE
360
VTDEDLNNHF
370
NSLGSNDLKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity |
| Biological Process | GO:0006574 | L-valine catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.