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Overview

Uniprot IDA0A5G2QUG8
Protein Name26S proteasome non-ATPase regulatory subunit 1
Gene NamePSMD1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
110 KCIDHYTKQCVENAD
146 QRCLDDHKYKQAIGI
148 CLDDHKYKQAIGIAL
310 TGSVLVGKTPEASPE
570 IESLCRDKDPILRRS
711 QFRQLYSKVINDKHD
799 KMPKVQYKSNCKPST

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MITSAAGIIS 20 LLDEEEPQLK 30 EFALHKLNAV 40 VNDFWAEISE 50 SVDKIEVLYE 60 DEGFRSRQFA 70 ALVASKVFYH 80 LGAFEESLNY 90 ALGAGDLFNV 100 NDNSEYVETI 110 IAKCIDHYTK 120 QCVENADLPE 130 GEKKPIDQRL 140 EGIVNKMFQR 150 CLDDHKYKQA 160 IGIALETRRL 170 DVFEKTILES 180 NDVPGMLAYS 190 LKLCMSLMQN 200 KQFRNKVLRV 210 LVKIYMNLEK 220 PDFINVCQCL 230 IFLDDPQAVS 240 DILEKLVKED 250 NLLMAYQICF 260 DLYESASQQF 270 LSSVIQNLRT 280 VGTPIASVPG 290 STNTGTVPGS 300 EKDSESMETE 310 EKTGSVLVGK 320 TPEASPEPKD 330 QTLKMIKILS 340 GEMAIELHLQ 350 FLIRNNNTDL 360 MILKNTKDAV 370 RNSVCHTATV 380 IANSFMHCGT 390 TSDDNLEWLA 400 RATNWAKFTA 410 TASLGVIHKG 420 HEKEALQLMA 430 TYLPKDTSPG 440 SAYQEGGGLY 450 ALGLIHANHG 460 GDIIDYLLNQ 470 LKNASNDIVR 480 HGGSLGLGLA 490 AMGTARQDVY 500 DLLKTNLYQD 510 DAVTGEAAGL 520 ALGLVMLGSK 530 NAQAIEDMVG 540 YAQETQHEKI 550 LRGLAVGIAL 560 VMYGRMEEAD 570 ALIESLCRDK 580 DPILRRSGMY 590 TVAMAYCGSG 600 NNKAIRRLLH 610 VAVSDVNDDV 620 RRAAVESLGF 630 ILFRTPEQCP 640 SVVSLLSESY 650 NPHVRYGAAM 660 ALGICCAGTG 670 NKEAINLLEP 680 MTNDPVNYVR 690 QGALIASALI 700 MIQQTEITCP 710 KVNQFRQLYS 720 KVINDKHDDV 730 MAKFGAILAQ 740 GILDAGGHNV 750 TISLQSRTGH 760 THMPSVVGVL 770 VFTQFWFWFP 780 LSHFLSLAYT 790 PTCVIGLNKD 800 LKMPKVQYKS 810 NCKPSTFAYP 820 APLEVPKEKE 830 KEKVSTAVLS 840 ITAKAKKKEK 850 EKEKKEEEKM 860 EVDEAEKKEE 870 KEKKKEPEPN 880 FQLLDNPARV 890 MPAQLKVLSM 900 PETCRYQPFK 910 PDLCSSEDFT ALYWKCL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008540 proteasome regulatory particle, base subcomplex
Molecular Function GO:0030234 enzyme regulator activity
Biological Process GO:0042176 regulation of protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.