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Overview

Uniprot ID	A0A5G2QUK6
Protein Name	Acetoacetyl-CoA synthetase
Gene Name	AACS
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
644	IPYTLNGKKVEVAVK

Function

Converts acetoacetate to acetoacetyl-CoA in the cytosol

Protein Sequence

10 MSKDTRAGQE 20 EILECQVMWE 30 PDSKKNTQMD 40 SFREAAGAVC 50 GLALENYDDL 60 YHWSVESYSD 70 FWAEFWKFSR 80 IVFSRMYDEV 90 VDTSKGISDV 100 PEWFKGSRLN 110 YAENLLQHKE 120 NDRVALYVAR 130 EGKEEILKVT 140 FEELRQQVAL 150 FAAAMRKMGV 160 KKGDRVVGYL 170 PNSVHAVEAM 180 LAAASIGAIW 190 SSTSPDFGVN 200 VSQGPCRCPG 210 YGVLDRFSQI 220 QPKLIFSVEA 230 VMYNGKEHGH 240 MDKLQQVVKG 250 LPDLEKVVVI 260 PYISSREKID 270 ISKMPNSVFL 280 EDFLATGKGE 290 QAPQLEFEQL 300 PFSHPLFIMF 310 SSGTTGAPKC 320 MVHSAGGTLI 330 QHLKEHILHG 340 NMTSSDIIFY 350 YTTVGWMMWN 360 WVVSALATGA 370 AVVLYDGSPL 380 VPTPNVLWDL 390 VDRIGITILG 400 TGAKWLSVLE 410 EKNMKPAETH 420 SLQTLHTILS 430 TGSPLKAQSY 440 EYVYRCIKSS 450 VLLGSISGGT 460 DIISCFMGQN 470 PCVPVYKGEI 480 QARNLGMAVE 490 AWNEEGKAVW 500 GERGELVCTK 510 PLPCQPTHFW 520 NDENGSKYRK 530 AYFSKFPGVW 540 AHGDYCRINP 550 KTGGIIMLGR 560 SDGTLNPNGV 570 RFGSSEIYNI 580 VEAFEEVMDS 590 LCVPQFNKDG 600 EERVILFLKM 610 ASGHTFQPDL 620 VKSIRNAIRL 630 GLSARHVPSL 640 ILETKDIPYT 650 LNGKKVEVAV 660 KQIIAGKAVE 670 HRGAFSNPET 680 LDLYRDIPEL QDF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0030729	acetoacetate-CoA ligase activity
Molecular Function	GO:0005524	ATP binding
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0032024	positive regulation of insulin secretion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.