Overview
| Uniprot ID | A0A5G2QUN4 |
|---|
| Protein Name | Phosphoserine aminotransferase |
|---|
| Gene Name | PSAT1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 117 |
KAAEEAKKFGTVNIV |
| 127 |
TVNIVHPKLGSYTKI |
| 310 |
PFRIGNTKGDDALEK |
| 317 |
KGDDALEKRFLDKAL |
| 322 |
LEKRFLDKALELKMI |
| 327 |
LDKALELKMISLKGH |
Function
Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. Acts as an inhibitor of ferroptosis in response to interferon-gamma (IFNG) by promoting GPX4 stability: following phosphorylation by CAMK2A, PSAT1 interacts with GPX4 and provides 2-oxoglutarate to EGLN3, leading to GPX4 hydroxylation and stability
Protein Sequence
10
MDSLMQVVNF
20
GAGPAKLPRS
30
VLLEIQKELL
40
DYKGVGISVL
50
EMSHRSSDFS
60
KIINNTENLV
70
RELLSIPDNY
80
KVIFVQGGGC
90
GQFSAVPLNL
100
IGLKAGRCAD
110
YVVTGSWSAK
120
AAEEAKKFGT
130
VNIVHPKLGS
140
YTKIPDPSTW
150
NLSPDASYVY
160
YCANETVHGV
170
EFDFIPDVKG
180
AVLVSDMSSN
190
FLSKPVDVSK
200
FGVIFAGAQK
210
NVGSAGVTVV
220
IVRDDLLGFA
230
LRECPSILDY
240
KVQAGNNSLY
250
NTPPCFSVYV
260
MGLVLEWIKN
270
NGGAAAMEKL
280
SCIKSQMIYD
290
IIDNSQGFYV
300
CPVEPQRSKM
310
NIPFRIGNTK
320
GDDALEKRFL
330
DKALELKMIS
340
LKGHRSVGGI
350
RASLYNAVTI
360
EDVQKLAAFM
KNFLEMHQL
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0004648 |
O-phospho-L-serine:2-oxoglutarate aminotransferase activity |
| Biological Process |
GO:0006564 |
L-serine biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.