Search Results
Overview
| Uniprot ID | A0A5G2QVA5 |
|---|---|
| Protein Name | Squalene synthase |
| Gene Name | FDFT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | SSLKTCYKYLNQTSR |
Function
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway
Protein Sequence
10
MQGWMSCEDP
20
DQDSLSSSLK
30
TCYKYLNQTS
40
RSFAAVIQAL
50
DGEMRHAVCI
60
FYLVLRALDT
70
LEDDMTISIE
80
KKIPLLHNFH
90
LHLYESDWRF
100
TESKEKDRQV
110
LEDFPTIALE
120
FRNLAEKYQV
130
VIVDVCRKMG
140
FGMAEFLNKH
150
VTSEREWDKY
160
CHYVAGLVGI
170
GLSRLFSASE
180
LEDPLVGEDT
190
ERANSMGLFL
200
QKTNIIRDYL
210
EDQQEGREFW
220
PQEVWSKYVK
230
KLGDFAKPEN
240
VDLAVQCLNE
250
LVTSTLHHIP
260
DVITYLSRLR
270
NQSIFNFCAI
280
PQVMAIATLA
290
ACYNNQQVFK
300
GVVKIRKGQA
310
VTLMMDATNM
320
PAVKAIIHQY
330
MEEIYHRIPD
340
SDPYSAKTRQ
350
IISTIRTQNL
360
PNCQLISRSH
370
YSPIYLSFVM
380
LLAALSWQYL
390
STLSQVTEDY
VQTGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0055056 | D-glucose transmembrane transporter activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051996 | squalene synthase [NAD(P)H] activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0045338 | farnesyl diphosphate metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.