Overview
| Uniprot ID | A0A5G2QVL1 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 1 |
|---|
| Gene Name | PTBP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 224 |
YIQFSNHKELKTDSS |
| 227 |
FSNHKELKTDSSPNQ |
| 349 |
TLRIDFSKLTSLNVK |
| 356 |
KLTSLNVKYNNDKSR |
| 484 |
YGDVQRVKILFNKKE |
| 526 |
PVRITLSKHQNVQLP |
| 544 |
QEDQGLTKDYGNSPL |
| 601 |
GGIVKGFKFFQKDRK |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MTRGLCPCGL
20
VTILLWVGLS
30
PWPGPAMGWP
40
IQALCRLGVG
50
AQKVERPVTC
60
SAPLGPLRWG
70
EELCLEVKDQ
80
RPLGVGRREG
90
QGVLGRGVGC
100
GKDTPFQPGH
110
LLQRGSDELF
120
SACVTNGPFI
130
MSSNSASTAN
140
GNDSKKFKGD
150
NRSAGVPSRV
160
IHIRKLPSDV
170
TEGEVISLGL
180
PFGKVTNLLM
190
LKGKNQAFIE
200
MNTEEAANTM
210
VNYYTSVTPV
220
LRGQPIYIQF
230
SNHKELKTDS
240
SPNQARAQAA
250
LQAVNSVQSG
260
NLALAASAAA
270
VDAGMAMAGQ
280
SPVLRIIVEN
290
LFYPVTLDVL
300
HQIFSKFGTV
310
LKIITFTKNN
320
QFQALLQYAD
330
PVSAQHAKLS
340
LDGQNIYNAC
350
CTLRIDFSKL
360
TSLNVKYNND
370
KSRDYTRPDL
380
PSGDNQPSLD
390
QTMAAAFGAP
400
GIMSASPYAG
410
AGFPPTFAIP
420
QAAGLSVPNV
430
HGALAPLAIP
440
SAAAAAAAAG
450
RIAIPGLAGA
460
GNSVLLVSNL
470
NPERVTPQSL
480
FILFGVYGDV
490
QRVKILFNKK
500
ENALVQMADG
510
SQAQLAMSHL
520
NGHKLHGKPV
530
RITLSKHQNV
540
QLPREGQEDQ
550
GLTKDYGNSP
560
LHRFKKPGSK
570
NFQNIFPPSA
580
TLHLSNIPPS
590
ISEEDLKILF
600
SSNGGIVKGF
610
KFFQKDRKMA
620
LIQMGSVEEA
630
IQALIDLHNH
640
DLGENHHLRV
SFSKSTI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0036002 |
pre-mRNA binding |
| Biological Process |
GO:0075522 |
IRES-dependent viral translational initiation |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0051148 |
negative regulation of muscle cell differentiation |
| Biological Process |
GO:0045665 |
negative regulation of neuron differentiation |
| Biological Process |
GO:0070886 |
positive regulation of calcineurin-NFAT signaling cascade |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.