Overview
| Uniprot ID | A0A5G2QW40 |
|---|
| Protein Name | Integrator complex subunit 9 |
|---|
| Gene Name | INTS9 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 547 |
PAQPVGGKKRKRASE |
Function
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex
Protein Sequence
10
KSTTIMLDCG
20
LDMTSTLNFL
30
PLPLVQSPRL
40
SNLPGWSLKD
50
GNAFLDKPHH
60
VDLCALHRYV
70
SFPPLSFQTE
80
LIDLSTVDVI
90
LISNYHCMMA
100
LPYITEHTGF
110
TGTVYATEPT
120
VQIGRLLMEE
130
LVNFIERVPK
140
AQSASLWKNK
150
DIQRLLPSPL
160
KDAVEVSTWR
170
RCYTMQEVNS
180
ALSKIQMVGY
190
SQKIELFGAV
200
QVTPLSSGYA
210
LGSSNWIIQS
220
HYEKVSYVSG
230
SSLLTTHPQP
240
MDQASLKNSD
250
VLILTGLTQI
260
PTANPDGMVG
270
EFCSNLALTV
280
RNGGNVLVPC
290
YPSGVIYDLL
300
ECLYQYIDSA
310
GLSSIPFYFI
320
SPVANSSLEF
330
SQIFAEWLCH
340
NKQTKVYLPE
350
PPFPHAELIQ
360
TNKLKHYPSI
370
HGDFSNDFRQ
380
PCVVFTGHPS
390
LRFGDVVHFM
400
ELWGKSSLNT
410
VIFTEPDFSY
420
LEALAPYQPL
430
AMKCIYCPID
440
TRLNFIQVSK
450
LLKEVQPLHV
460
VCPEQYTQPP
470
PAQSHRMDLM
480
IDCQPPAMSY
490
RRAEVLALPF
500
KRRYEKIEIM
510
PELADSLVPM
520
EIKPGISLAT
530
VSAVLHTKDN
540
KHVLQPPPRP
550
AQPVGGKKRK
560
RASEEVPDCK
570
VVKPLLSGSI
580
PVEQFVQTLE
590
KHGFSDIKVE
600
DTAKGHIVLL
610
QEAETLIQIE
620
EDSTHIICDN
630
DEMLRVRLRD
LVLKFLQKF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0160232 |
INTAC complex |
| Cellular Component |
GO:0032039 |
integrator complex |
| Biological Process |
GO:0090101 |
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| Biological Process |
GO:0090287 |
regulation of cellular response to growth factor stimulus |
| Biological Process |
GO:0160240 |
RNA polymerase II transcription initiation surveillance |
| Biological Process |
GO:0034472 |
snRNA 3'-end processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.