Overview
| Uniprot ID | A0A5G2QW88 |
|---|
| Protein Name | Ras-related protein Rab-18 |
|---|
| Gene Name | RAB18 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 124 |
VDRNEGLKFARKHSM |
| 172 |
ENQNKGVKLTHREEG |
| 34 |
ARVDFKVKTISVDGN |
| 42 |
TISVDGNKAKLAIWD |
| 44 |
SVDGNKAKLAIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration
Protein Sequence
10
AVLFHLWRFL
20
EDWAQTFLCV
30
NCFCSCARVD
40
FKVKTISVDG
50
NKAKLAIWDT
60
AGQERFRTLT
70
PSYYRGAQGV
80
ILVYDVTRRD
90
TFVKLDNWLN
100
ELETYCTRND
110
IVNMLVGNKI
120
DKENREVDRN
130
EGLKFARKHS
140
MLFIEASAKT
150
CDGVQCAFEE
160
LVEKIIQTPG
170
LWESENQNKG
180
VKLTHREEGQ
190
GGGACGGYCS
VL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.