Search Results
Overview
| Uniprot ID | A0A5G2QWB2 |
|---|---|
| Protein Name | Heme oxygenase |
| Gene Name | HMOX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 39 | EFMKNFQKGEVTREG |
Function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis
Protein Sequence
10
MEHSQPNSVP
20
QDLSEALKEA
30
TKEVHVQAEN
40
AEFMKNFQKG
50
EVTREGFKLV
60
MASLYHIYDA
70
LEEEIEHNKE
80
NPVYTPLYFP
90
EELHRRAALE
100
QDMAFWYGPR
110
WQEAIPYTQA
120
TKRYVRRLQQ
130
VGRFEPELLV
140
AHAYTRYGDL
150
SGGQVLKKIA
160
QKALDLPSSG
170
EGLAFFTFPN
180
VANATKFKQL
190
YRSRMNTLEM
200
TPEVKQRVLE
210
EAKTAFLLNI
220
QLFEEVQELL
230
TQDTKDQRPS
240
QASDVRKRAG
250
SRVQDSTPVT
260
TPRGKPQLSV
270
LSQVPLVRWV
280
LTLSFLVATV
AMGLYAM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0004392 | heme oxygenase (decyclizing) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:0034101 | erythrocyte homeostasis |
| Biological Process | GO:0042167 | heme catabolic process |
| Biological Process | GO:0006788 | heme oxidation |
| Biological Process | GO:0043922 | host-mediated suppression of viral transcription |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0060586 | multicellular organismal-level iron ion homeostasis |
| Biological Process | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| Biological Process | GO:1903901 | negative regulation of viral life cycle |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:1903589 | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| Biological Process | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Biological Process | GO:0035094 | response to nicotine |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0002246 | wound healing involved in inflammatory response |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.