Overview
| Uniprot ID | A0A5G2QWD8 |
|---|
| Protein Name | Low density lipoprotein receptor adapter protein 1 |
|---|
| Gene Name | LDLRAP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 72 |
ELSAAAVKRIVATAK |
Function
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression
Protein Sequence
10
MDALKSAGRA
20
LIRSPSLAKQ
30
SWGGSGRHRK
40
LPENWTDTRE
50
TLLEGMLFSL
60
KYLGMTLVEQ
70
PKGEELSAAA
80
VKRIVATAKA
90
SGKKLQKVTL
100
KVSPRGIILT
110
DSITNQLIEN
120
VSIYRISYCT
130
ADKMHDKVFA
140
YIAQSQHNEN
150
LECHAFLCTK
160
RKMAQAVTLT
170
VAQAFKVAFE
180
FWQVSKEEKE
190
KREKASQEGG
200
DALGGGRRDS
210
APSSKSLVAT
220
GNLLDLEETA
230
KAPLSTVSAN
240
TTNMDEAPRP
250
QALNSSSVVW
260
ELDDGLDEAF
270
SSAGQAELAP
280
QAPASPLPGP
290
PAHTALPSRL
300
AQSRTNPHVL
310
DTGLTAQDLQ
320
YAQCLSPVDW
330
DKPDSSGAEP
DDLFNF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009925 |
basal plasma membrane |
| Cellular Component |
GO:0009898 |
cytoplasmic side of plasma membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0005883 |
neurofilament |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Molecular Function |
GO:0001540 |
amyloid-beta binding |
| Molecular Function |
GO:0035650 |
AP-1 adaptor complex binding |
| Molecular Function |
GO:0035612 |
AP-2 adaptor complex binding |
| Molecular Function |
GO:0035615 |
clathrin adaptor activity |
| Molecular Function |
GO:0030276 |
clathrin binding |
| Molecular Function |
GO:0050750 |
low-density lipoprotein particle receptor binding |
| Molecular Function |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function |
GO:0001784 |
phosphotyrosine residue binding |
| Molecular Function |
GO:0030159 |
signaling receptor complex adaptor activity |
| Biological Process |
GO:0042982 |
amyloid precursor protein metabolic process |
| Biological Process |
GO:0071345 |
cellular response to cytokine stimulus |
| Biological Process |
GO:0042632 |
cholesterol homeostasis |
| Biological Process |
GO:0008203 |
cholesterol metabolic process |
| Biological Process |
GO:0034383 |
low-density lipoprotein particle clearance |
| Biological Process |
GO:1905581 |
positive regulation of low-density lipoprotein particle clearance |
| Biological Process |
GO:1905602 |
positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| Biological Process |
GO:1904707 |
positive regulation of vascular associated smooth muscle cell proliferation |
| Biological Process |
GO:0031623 |
receptor internalization |
| Biological Process |
GO:0090118 |
receptor-mediated endocytosis involved in cholesterol transport |
| Biological Process |
GO:1903076 |
regulation of protein localization to plasma membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.